Cell death, or “cellular suicide”. Most cells in the body have a specific role, they divide in an organized manner and their life cycle is defined, thus they die and new cells are generated. Cancer cells miss both the apoptosis mechanism and the mechanism in charged of their normal division.
- Chemotherapy
When my oncologist will consider Chemotherapy treatment for me?
If you diagnosed with cancer Chemotherapy treatment might be considered. Chemotherapy is a medicated therapy which aims to shrink and erase cancerous cells and allow control over the disease.and what are the side effects?
Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body. Chemotherapy usually has serious side effects with varying degrees of difficulty and you may experience hair loss, loss of appetite, changes in exits, fatigue, infections, bleeding, pain, mood changes, muscle pain, loss of fertility and more. Please share it with your HCPsHow do I get the chemotherapy?
There are different types of chemotherapy The common is intravenous infusion There are chemotherapy drugs that are given orally by a pill. - Breast Cancer Surgery
When my oncologist will consider breast cancer surgery for me?
If you diagnosed with non-metastatic breast cancer surgery is a first and preferred option according to all standard protocols. The surgery’s goal is to remove the tumor in its entirety without harming the breast or its function. At present, multiple innovative surgeries are offered to patients, which allow reduction of the health and cosmetic damages caused to the breast. It is considered a success when a tumor is removed in full, however, not all surgeries are necessarily so. At times the tumor is branched and can only be partially removed. In patients with genetic disposition there are cases where both breasts are removed in order to prevent a recurrence of the disease, for example patients who are BRCA gene carriers.What kinds of breast cancer surgery can be right for me?
There are several types of surgeries that your oncologist may consider for you, and this of course depends on the size of the tumor, the Stage and its location, for example:- Partial removal - Breast-conserving Surgery (Lumpectomy)
- Complete removal - Mastectomy, sometimes radical mesectomy will be done
- Prophylactic Mastectomy
- Breast-conserving Surgery (Lumpectomy)
Two main types of treatment may be offered to patients before and after breast cancer surgery
- Treatment prior to surgery is known as ‘Neoadjuvant'
- Post-surgery treatment, also known as ‘Adjuvant’
- ToriselTorisel®, temsirolimus,
- Renal cell carcinoma - Torisel is indicated for the first-line treatment of patients with advanced renal cell carcinoma (RCC)
- Mantle cell lymphoma - Torisel is indicated for the treatment of adult patients with relapsed and/or refractory mantle cell lymphoma (MCL)
- SutentSutent®, Sunitinib, is anti cancer drug indicated for:
- For treatment of gastrointestinal stromal tumor, GIST.
- For treatment of advanced renal cell carcinoma, aRCC.
- For treatment of differentiated pancreatic neuroendocrine tumors, pNET, that have progressed or cannot be removed with surgery.
- VotrientVotrient®, Pazopanib, is a type of medicine called a protein kinase inhibitor. It works by inhibiting the activity of proteins that are involved in the growth and spread of cancer cells. Votrient is used in adults to treat:
- kidney cancer that is advanced or has spread to other organs
- certain forms of soft tissue advanced sarcoma - a type of cancer that affects the supportive tissues of the body. It can occur in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect the organs.
- XtandiXtandi®, Enzalutamide, is indicated for:
- the treatment of adult men with high-risk non-metastatic castration-resistant prostate cancer (CRPC)
- the treatment of adult men with metastatic CRPC who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated
- the treatment of adult men with metastatic CRPC whose disease has progressed on or after docetaxel therapy
- EulexinEulexin®, Flutamide is indicated for use in combination with LHRH agonistic analogues for the treatment of metastatic prostatic carcinoma (stage d2). To achieve the benefit of the adjuctive therapy with eulexin, treatment must be started simultaneously using both drugs.
- FrimagonFrimagon®, Degarelix, is anti cancer drug indicated for the treatment of adult male patients with advanced hormone dependent prostate cancer.
- DecapeptylDecapeptyl, Triptorelin, is indicated for precocius puberty, prostatic cancer, endomethriosis, uterus myomatoses and IVF
- PalbociclibIbrance®, palbociclib, is a kinase inhibitor indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in combination with • an aromatase inhibitor as initial endocrine based therapy in postmenopausal women e.g. Letrozole or • fulvestrant in women with disease progression following endocrine therapy To Read More>>
- BicalutamideBicalutamide is anti cancer drug for the treatment of advanced prostate cancer in combination with LHRH analog therapy or surgical castration.
- CasodexCasodex is the brand name of Bicalutamide - for prostate cancer
- ErleadaErleada®, Apalutamide, is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration resistant prostate cancer, NM-CRPC.
- Abiraterone acetateAbiraterone acetate is a prescription drug, hormone therapy, that inhibits CYP17 enzyme, and is given together with prednisone for the treatment of men with metastatic castration resistant prostate cancer who have already received prior chemotherapy containing docetaxel.
- ZytigaZytiga® is the commercial name of the hormonal drug Abiraterone Acetate
- JeventaJeventa® is the brand name of the chemotherapy medication - Cabazitaxel Jeventa® is indicated in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel- containing treatment regimen.
- NeutropeniaLow level of neutrophil See Neutrophil
- NeutrophilA type of white blood cell that helps the body fight infections
- FolfirinoxFolfirinox is a combination of 4 anti Pancreatic Cancer drugs:
- Leucovorin - Folinic acid
- Adrucil®, (Fluorouracil, 5-FU) - chemotherapy
- Camptosar®, Campto®, (Irinotecan) - chemotherapy
- Eloxatin®, (Oxaliplatin) - chemotherapy
- Targeted TherapyTargeted Therapy works by targeting specific genes or proteins to help stop cancer growth and spread. Herceptin, Herceptin®, for breast cancer is an anti-HER2 antibody that belongs to this family of treatments.
- CTn imaging procedure in which a computer is connected to an X-ray machine and creates a series of detailed pictures of different areas of the body. Each tissue in the body absorbs radiation and returns radiation differently. The pictures are taken from different angles and are then processed to create a three-dimensional picture. Sometimes a contrast substance is injected into a vein or can be swallowed. The contrast material causes the tissues and organs to appear more clearly. CT can be used to help diagnose diseases, plan treatment, or find out how treatment works. The test is also called CT scan, CAT scan.
- NUT midline carcinomaA rare and particularly violent type of squamous cell epithelium cancer which usually appears in the midline of the body and most often characterized by a mutation called NUTM1. United States reports 20-30 cases a year.
- BRAFProtein in a cell that participates in cell division processes and is also an oncogen. BRAF mutations appear in different cancers. The drugs and Moraphenib (generic name: Vemurafenib, trade name: Zelboraf®) and Debrafenib (generic name: Tafinlar®) are given to patients with mutations in BRAF.
- Multikinase inhibitorMultikinase inhibitor are group of drugs which has demonstrated both anti proliferative and antiangiogenic properties. For example: Sorafenib
- SorafenibNexavar®, Sorafenib is anti cancer drug multikinase inhibitor, film coated tablets, indicated for the treatment of:
- Renal cell carcinoma Nexavar is indicated for the treatment of patients with advanced renal cell carcinoma.
- Hepatocellular Carcinoma Nexavar is indicated for the treatment of patients with hepatocellular carcinoma see section
- Differentiated thyroid carcinoma Nexavar is indicated for the treatment of patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma, refractory to radioactive iodine.
- CNS HGNET-BCORCNS HGNET-BCOR, Central Nervous System Gigh Grade Neuroepithelial Tumor with BCOR alteration, is a rare cancerous tumor develop in the central nervous system, CNS, among young children.
- BCORBCOR is a gene that encodes BCL-6 corepressor protein.
- NeuroblastomaNeuroblastoma is is a type of cancer which originates in nervous system. It is most commonly starts in adrenal gland, but it can also develop in the neck, chest, stomach, or pelvis. The disease is common among infants and children.
- DIPGDIPG, diffuse Intrinsic Pontine Glioma, is a type of cancer which originates in the brain and made of brain cells known as “gliomas.” DIPG is a pediatric disease. The average age of diagnosis is 4 to 11, and the disease accounts for about 10-15% of all brain tumors among children. Some adults have the disease as well.
- Metastatic melanoma
What is metastatic melanoma?
Metastatic melanoma, Stage 4 or stage IV melanoma is a cancer that started in a spot, sore or mole and its cells have spread to other body organs, distant from the origin, where they created new lesions. These lesions are called “metastases” and are made of melanoma cancer cells. Melanoma cancer metastases may appear in the bones, liver, lungs and brain. The formation of metastases is life-threatening. Even though the cancer has spread to other organs, it is still defined as a melanoma cancer and is treated as such. In this manner for example, a lesion in the lung that is a metastasis of melanoma cancer shall be treated with melanoma drugs and not lung cancer drugs.What are the causes of metastatic melanoma?
The main cause of skin cancer is exposure to the sun’s rays, particularly ultra-violet (UV) rays. Light toned skin, a tendency to moles and freckles, a family history of skin cancer, and older age, constitute risk factors for skin cancer. The primary recommendation for people belonging to these categories is to avoid direct exposure to the sun and be sure to use sun protection, such as sunscreen lotions, sunglasses, and clothes with full body cover.What are the advanced treatments for melanoma?
The existing therapies used on stage 4 metastatic melanoma are not curative and this is a source to the need for innovative and effective treatment strategies in order to fight the disease. The National Cancer Institute, NCI, highlights the fact that for stage 4 melanoma patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success. Currently, every patient will be offered the standard protocols. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute. Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have... - Keytruda® PriceKetruda® is a cancer drug which belongs to the group of immunotherpy drugs. This drug is FDA approved for different cancer indications and may also be available through: Clinical trials. There are numerous clinical trials with Ketruda® around the globe where cancer patients may be enrolled and receive it for free as long as they participate in the trial Private health insurance coverage for cancer drugs. The cost of Ketruda® is
- 50 ml vial - around 2,600$ US
- 100 ml - around 4,300$ US
- Breast cancer agesBreast cancer incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2013-2015, on average each year a quarter (25%) of new cases were in people aged 75 and over. Age-specific incidence rates rise steadily from around age 30-34 and more steeply from around age 70-74. The highest rates are in the 90+ age group for males and the 85 to 89 age group for females. Incidence rates are significantly lower in males than females in a number of (mainly older) age groups. The gap is widest at age 45 to 49, when the age-specific incidence rate is 423 times lower in males than females. To Read More>>
- Breast Cancer in MenBreast cancer in men occurs in about 1% of the total breast cancer cases. It is mostly appears after the age of 50 and for genetic tendency among men with BRCA1, BRCA2 gene mutations. It can also appear in men who have breast tissue, who were exposed to estrogen, have hormonal imbalance and more. Disease management includes diagnosis, follow-up and treatment similar to breast cancer in women.
- Keytruda side effectsKeytruda® is a medicine that may treat certain cancers by working with the immune system, also called immunotherapy. Keytruda can cause the immune system to attack normal organs and tissues in any area of the body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death. Common side effects of Keytruda include: feeling tired, pain in muscles, bones or joints, decreased appetite, itching, diarrhea, nausea, rash, fever, cough, shortness of breath, and constipation. In children, feeling tired, vomiting and stomach-area (abdominal) pain, and increased levels of liver enzymes and decreased levels of salt (sodium) in the blood are more common than in adults. Call or see your doctor right away if you develop any symptoms of the following problems or these symptoms get worse:
- Lung problems (pneumonitis). Symptoms of pneumonitis may include: shortness of breath, chest pain, new or worse cough.
- Intestinal problems (colitis) that can lead to tears or holes in the intestine. Signs and symptoms of colitis may include: diarrhea or more bowel movements than usual, stools that are black, tarry, sticky, or have blood or mucus, severe stomach-area (abdomen) pain or tenderness.
- Liver problems (hepatitis). Signs and symptoms of hepatitis may include: yellowing of the skin or the whites of the eyes, nausea or vomiting, pain on the right side of the stomach area (abdomen), dark urine, feeling less hungry than usual, bleeding or bruising more easily than normal.
- Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas). Signs and symptoms that the hormone glands are not working properly may include: rapid heart beat, weight loss or weight gain, increased sweating, feeling more hungry or thirsty, urinating more often than usual, hair loss, feeling cold, constipation, the voice gets deeper, muscle aches, dizziness or fainting, headaches that will not go away or unusual...
- KeytrudaKeytruda®, Pembrolizumab, is an innovative, anti cancer monoclonal antibody immunotherapy drug. The drug blocks the link between the cancer cell PD-L1 ligand, to a patient's immune system PD-1 receptor , helping the immune system kill the cancer cells. To read more:
- Acral melanomaAcral melanoma is Melanoma that appears in the hands, feet, or under the nails
- Pancreatic cancer symptomsPancreatic cancer is usually discovered in later stages, as this is an internal organ. Early detection of cancer greatly increases the chances for successful treatment and on therapeutic success. Therefore, it is recommended to consult with a specialist regarding the appearance of any of the following symptoms:
- Jaundice (yellowing of the skin and the white of the eyes)
- Pain in the upper or middle abdomen and in the back
- An unexplained loss of weight
- Loss of appetite
- Diabetes
- Fatigue
- Depression
- Bone pain (such as back pain or pain in the thighs)
- Changes in the nervous system, such as: headaches, weakness or numbness of the arm or leg, dizziness, balancing issues or attacks
- Appearance of lumps close to the body’s surface
- Keytruda
What is Keytruda (Keytruda®)?
Keytruda, pembrolizumab, is a prescription medicine, an innovative breakthrough drug, humanized monoclonal antibody. Keytruda belongs to the “immunotherapy” drugs that help the immune system attack the tumor. This contrasts, for example, with chemotherapy that directly affects tumor cells. Keytruda and immunotherapy is therapeutic strategy has revolutionized the treatment of cancer in recent years and is one of the most studied strategies in the world for many types of cancer and different stages of treatments.What is Keytruda used for?
Keytruda is prescribed by an oncologist and is used to treat various types of cancer, for example: Advanced melanoma skin cancer when the disease has spread or cannot be removed by surgery. Advanced non small cell lung cancer, NSCLC, for patients with positive for PDL1 and not received chemotherapy and the tumor express EGFR or ALK gene/mutation. Other cases can be for patients who received platinum chemotherapy and it is no longer working and the patients tumor express EGFR or ALK gene/mutation. Other cases can be patients that also received an EGFR or ALK inhibitor medicine and it did not work any more. Advanced head and neck squamous cells cancer, HNSCC. if the disease has returned or spread and previous platinum chemotherapy is no longer working. Hodgkin lymphoma, cHL, in adults and children if the disease has returned and if the patients received 3 or more types of treatment. Bladder and urinary tract cancer, urothelial carcinoma – for metastatic disease or patients who can not receive cisplatin, or cases of a disease that progresses during chemotherapy treatment. Cancer types among adults and children that is shown by a laboratory test to be a microsatellite instability high (MSI-H), or a mismatch repair deficient (dMMR) solid tumor. Here there are a few points to consider, for example the cancer has spread or cannot be removed by surgery and there are no... - Breast Cancer Symptoms
Changes in the breast, nipple or armpits in women and men may be a warning sign for the development of breast cancer but not necessarily.
Early detection has a decisive influence on how the disease is treated and on treatment outcomes.
Therefore, it is recommended that you consult a specialist physician for the appearance of any of the following symptoms:
- Lump or swallowing of the breast - Can be manually felt or seen in an ultrasound or mammogram examination.
- Nipple inversion - Reverses the side of the nipple and pulls it into the breast, enlarged nipple, bleeding, swelling, inflammatory or pulled inside.
- Lumps in the armpit - Can be manually felt or seen in an ultrasound or mammogram examination.
- Redness, inflammation, or rash (Redness / Rash) - Redness or rash that are sometimes accompanied by itching, on the breast, on the nipple, on one or two of the breasts.
- Bloody Discharge from the nipple - A bloody nipple discharge on one side or both nipples.
- Yellow Discharge from the nipple - White, yellow, translucent or other colors in one or both nipples.
- Sink in the breast or texture of "orange peel" (Dimpling) - Skin roughness or thickening of tissue in the breast or near the armpit, sometimes accompanied by a feeling of local redness and heat.
- Changes in the texture of the skin and color (Texture Change) - Changes in the appearance of the breast, or drooping of the breast a feeling of local redness and heat.
- Astrocytoma
- Anaplastic astrocytomaAnaplastic astrocytoma is a type of stage 3 cancer tumor which originates in the brain and made of brain cells known as “gliomas.”
- LucrinLucrin®, Leuprolide, is a gonadotropin releasing hormone (GnRH) agonist indicated for endometriosis, prostatic cancer, treatment of uterine fibroids for a period of up to six months. Treatment of breast cancer in pre- and peri - menopausal women in whom hormone therapy is specified.
- ZoladexZoladex®, goserelin, is anti cancer drug, belongs to a group of medicines called: LHRH analogues. Therapeutic activity Information for men:
- For treatment of prostate cancer. Zoladex works by lowering the levels of 2 testosterone, a hormone produced by the body.
- In women, Zoladex works by lowering the levels of estrogen, a hormone produced by the body.
- For treatment of breast cancer in premenopausal women.
- For treatment of endometriosis – a disease of the womb lining (a condition where pain is caused by excess tissue which grows within or outside of the womb).
- Helps fertility by preparing for superovulation.
- Uterine fibroids (benign growths that appear in the womb), to decrease the size of fibroids before surgery.
- Prethinning of the womb lining before surgery.
- AlimtaAlimta®, pemetrexed, is a anti cancer drug folate analog metabolic inhibitor indicated:
- in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous NSCLC, with no EGFR or ALK genomic tumor aberrations.
- in combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous, non-small cell lung cancer (NSCLC).
- as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.
- as a single agent for the treatment of patients with recurrent, metastatic non-squamous, NSCLC after prior chemotherapy. Limitations of Use: Alimta is not indicated for the treatment of patients with squamous cell, non-small cell lung cancer.
- initial treatment, in combination with cisplatin, of patients with malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery.
- LynparzaLynparza, olaparib, is anti cancer drug called a PARP inhibitor. PARP inhibitors can trigger the death of cancer cells by blocking an enzyme that helps repair DNA. Lynparza is intended for:
- for the treatment of ovarian cancer in patients carrying the BRCA mutation whom have responded to previous platinum-based chemotherapy. A test is used to determine whether the cancer you are suffering from has the BRCA mutation.
- for the treatment of metastatic breast cancer in patients with mutations in BRCA and HER2-negative, who have been treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting. If you have hormone receptor (HR)-positive disease, the recommendations are treatment with endocrine therapy.
- AfinitorAfinitor® , Everolimus ia an anti cancer drug which reduces the blood supply to cancer cells and can thus reduce the growth and spread of cancer cells. Afinitor can also reduce the size of kidney tumors called renal angiomyolipomas and brain tumor cells of the SEGA type, the latter two tumors are caused by a genetic disorder called Tuberous Sclerosis Complex (TSC). Indications:
- Treatment of patients with a brain tumor of the Subependymal Giant Cell Astrocytoma , SEGA, type associated with Tuberous Sclerosis Complex - TSC.
- Treatment of adult patients with a kidney tumor known as Angiomyolipoma ,AML, when the kidney tumor does not require immediate surgery. This type of tumor is connected with a genetic condition known as Tuberous Sclerosis Complex.
- Treatment of patients with advanced neuroendocrine tumors of pancreatic origin that cannot be surgically removed, that are locally advanced or have metastasized.
- Treatment of advanced hormone receptor-positive and HER2-negative breast cancer in conjunction with exemestane, in postmenopausal women without symptomatic metastatic disease spread to internal organs, after recurrence or progression of the disease, following treatment with nonsteroidal aromatase inhibitors.
- For treatment of advanced kidney cancer (Advanced Renal Cell Carcinoma ,RCC), where other treatments (so-called “VEGF-targeted therapy”) have not helped stop your disease.
- For the treatment of locally advanced, metastatic or unresectable, well-differentiated (1 or 2) non-functional neuroendocrine tumors of lung or gastrointestinal origin in adults with progressive disease.
- VerzenioVerzenio®, abemaciclib, is indicated for treatment of breast cancer
- In combination with a non-steroidal aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer
- in combination with fulvestrant for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer with disease progression following endocrine therapy
- as monotherapy for the treatment of adult patients with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy in the metastatic setting and prior chemotherapy in the metastatic setting including taxane in adjuvant or metastatic setting. Verzenio should not be used in women after prior treatment with cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) inhibitor
- KisqaliKisqali, Ribociclib, is used to treat postmenopausal women with locally advanced or metastatic breast cancer, that is HR positive and HER2 negative, in combination with a non-steroidal aromatase inhibitor, as initial endocrine based-therapy. Therapeutic group: Cyclin-dependent kinase enzyme inhibitors. Kisqali contains the active ingredient ribociclib, which belongs to a group of medicines called cyclin-dependent kinase (CDK) inhibitors. Kisqali works by blocking proteins called cyclin-dependent kinases 4 and 6, which are important for the growth and division of cells. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer. To Read More>>
- TykerbTykerb®, lapatinib, is used to treat certain types of breast cancer (HER2-overexpressing) which have spread beyond the original tumour or to other organs (advanced or metastatic breast cancer). It may slow or stop cancer cells from growing, or may kill them. Tykerb is given in combination with other anticancer medicines. Tykerb is given in combination with capecitabine, for patients who have had treatment for advanced or metastatic breast cancer before. This previous treatment for the metastatic breast cancer must have included an anthracycline, a taxane and trastuzumab. Tykerb is given in combination with letrozole, for postmenopausal women with hormone receptor positive metastatic breast cancer that overexpress HER2 and who are candidates for hormonal therapy. To Read More>>
- KadcylaKadcyla, is approved to treat human epidermal growth factor 2 (HER2) positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin®) and a taxane. Prior treatment could have been for the initial treatment of breast cancer or for the treatment of cancer that had spread to other parts of the body. To Read More>>
- PerjetaPerjeta®, pertuzumab, is approved for use in combination with Herceptin® (trastuzumab) and docetaxel in people who have HER2 positive breast cancer that has spread to different parts of the body (metastatic) and who have not received anti HER2 therapy or chemotherapy for metastatic breast cancer. Perjeta® is approved for use in combination with Herceptin® (trastuzumab) and chemotherapy for:
- use prior to surgery (neoadjuvant treatment) in people with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (tumor is greater than 2 cm in diameter or node-positive). PERJETA should be used as part of a complete treatment regimen for early breast cancer.
- use after surgery (adjuvant treatment) in people with HER2-positive early breast cancer that has a high likelihood of coming back.
- FemaraFemara® is the commercial name for letrozole
- letrozoleFemara®, letrozole, is anti cancer drug, a form of hormone therapy known as an aromatase inhibitor, which works by reducing the amount of estrogen in postmenopausal women. This medicine is a hormonal (or “endocrine”) breast cancer treatment. Growth of breast cancer is frequently stimulated by oestrogens, which are female sex hormones. Femara reduces the amount of oestrogen by blocking an enzyme (“aromatase”) involved in the production of oestrogens and may therefore block the growth of breast cancers that need oestrogen to grow. As a consequence, tumour cells slow down or stop growing and/or spreading to other parts of the body. Indications:
- Adjuvant treatment of early-stage breast cancer in postmenopausal women.
- Extended adjuvant treatment of early-stage breast cancer in postmenopausal women following standard adjuvant tamoxifen therapy.
- Treatment of advanced or metastatic breast cancer in postmenopausal women.
- Treatment of advanced breast cancer in postmenopausal women with disease progression following treatment with antioestrogens.
- ArimidexArimidex®, Anastrozole is a drug to treat breast cancer in post-menopausal women by aromatase enzyme inhibition To Read More>>
- ExemasinExemasin is anti cancer drug indicated for the treatment of advanced breast cancer (ABC) in women with natural or induced postmenopausal status whose disease has progressed following anti estrogen therapy alone. Exemasin is also indicated for the treatment of postmenopausal women with ABC whose disease has progressed following multiple hormonal therapies. Exemasin is indicated for the adjuvant treatment of postmenopausal women with estrogen receptor positive invasive early breas cancer following 2-3 years of initial adjuvant tamoxifen therapy
- FaslodexFaslodex®, Fulvestrant is anti cancer drug for breast cancer. Faslodex indicated for treatment of oestrogen receptor positive, locally advanced or metastatic breast cancer in postmenopausal women not previously treated with hormonal therapy, or with disease relapse/progression on or after adjuvant endocrine therapy Faslodex, in combination with the preparation palbociclib, is intended for women with advanced or metastatic estrogen receptor-positive and HER2-negative breast cancer, whose disease has progressed after receiving prior hormonal treatment for this ailment. When used in combination with palbociclib (Ibrance), please read the palbociclib (Ibrance) patient package insert as well. Faslodex belongs to the group of medicines that block the activity of estrogen. To Read More>> Ask your Oncologist how to use Faslodex if you are not sure. The dosage and duration of Faslodex treatment will be determined by the doctor only. Read the patient leaflet guide which is enclosed to each package.
- TamoxifenTamoxifen is anti cancer drug that wad initially made in 1962 and indicated for:
- hormonal breast cancer
- ovarian cancer
- VinorelbineVinorelbine is a chemotherapy כor the treatment of non small cell lung cancer and for the treatment of advanced breast cancer
- Vinorelbin “Ebewe”Navelbine® is the brand name of the chemotherapy medication - Vinorelbine
- NavelbineNavelbine® is the brand name of the chemotherapy medication - Vinorelbine
- DocetaxelDocetaxel is a chemotherapy indicated for: Breast Cancer
- Docetaxel in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer.
- Docetaxel in combination with doxorubicin is indicated for the treatment of patients with locally advanced or metastatic breast cancer who have not previously received cytotoxic therapy for this condition.
- Docetaxel monotherapy is indicated for the treatment of patients with metastatic breast cancer after failure of cytotoxic therapy. Previous chemotherapy should have included an anthracycline or an alkylating agent.
- Docetaxel in combination with trastuzumab is indicated for the treatment of patients with metastatic breast cancer whose tumors over-express HER2 and who previously have not received chemotherapy for metastatic disease.
- Docetaxel in combination with capecitabine is indicated for the treatment of patients with metastatic breast cancer after failure of cytotoxic chemotherapy. Previous therapy should have included an anthracycline.
- Doxorubicin and cyclophosphamide followed by docetaxel in combination with trastuzumab (AC-TH) is indicated for the adjuvant treatment of patients with HER2 overexpressing, node-positive or high risk node-negative, breast cancer.
- Docetaxel in combination with trastuzumab, and carboplatin (TCH) is indicated for the adjuvant treatment of patients with HER2 over-expressing, node-positive or high risk node-negative, breast cancer.
- Docetaxel is indicated for the treatment of patients with advanced non-small cell lung carcinoma.
- Docetaxel is indicated for treatment of metastatic carcinoma of the ovary after failure of first line or subsequent chemotherapy.
- Docetaxel in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone refractory metastatic prostate...
- Docetaxel HospiraDocetaxel Hospira® is the brand name of the chemotherapy medication - Docetaxel
- Docetaxel EbeweDocetaxel Ebewe® is the brand name of the chemotherapy medication - Docetaxel
- CarboplatinCarboplatin is anti cancer chemotherapy drug, used alone or in combination with other antineoplastic agents in the treatment of:
- advanced ovarian cancer
- advanced breast cancer
- metastatic small cell lung cancer
- HerceptinHerceptin® (trastuzumab)is anti cancer drug for: Adjuvant Breast Cancer Herceptin is indicated for adjuvant treatment of HER2 overexpressing node positive or node negative (ER/PR negative or with one high risk feature breast cancer
- as part of a treatment regimen consisting of doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel
- as part of a treatment regimen with docetaxel and carboplatin
- as a single agent following multi-modality anthracycline based therapy. Select patients for therapy based on an FDA-approved companion diagnostic for Herceptin
- In combination with paclitaxel for first-line treatment of HER2-overexpressing metastatic breast cancer
- As a single agent for treatment of HER2-overexpressing breast cancer in patients who have received one or more chemotherapy regimens for metastatic disease. Select patients for therapy based on an FDA-approved companion diagnostic for Herceptin
- COX-2 InhibitorsMolecules belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit COX2 enzyme, which is involved in inflammation and pain processes. It was found that this enzyme is also involved in the growth of cancer cells. The FDA has approved a drug called "Celebrex" for FAP, a condition that raises the risk of colorectal cancer (see family polyposis).
- MRIImaging method based on radio waves and a magnet. The images produced by this method can show the difference between normal and diseased tissues.
- Magnetic resonance imagingImaging method based on radio waves and a magnet. The images produced by this method can show the difference between normal and diseased tissues.
- Sedimentation rateBlood test that measures how far red blood cells travel in one hour in a blood sample as they settle into the bottom of the tube. The rate of ESR increases with inflammation, infection, and also in cancer. Also called sedimentation rate. Erythrocyte sedimentation rate, ESR
- ESRBlood test that measures how far red blood cells travel in one hour in a blood sample as they settle into the bottom of the tube. The rate of ESR increases with inflammation, infection, and also in cancer. Also called sedimentation rate. Erythrocyte sedimentation rate, ESR
- ERCP
Endoscopic Retrograde Cholangio pancreatography, ERCP
A procedure that allows the physitian to examine the pancreatic duct, hepatic duct, common bile duct, duodenal papilla and gallbladder by inserting an endoscope through the mouth into the first part of the small intestine (duodenum). A smaller tube (catheter) is then inserted through the endoscope into the bile and pancreatic ducts. A colored substance (dye) is injected through the catheter for x-ray imaging.
- ERCP
Endoscopic Retrograde Cholangio pancreatography, ERCP
A procedure that allows the physitian to examine the pancreatic duct, hepatic duct, common bile duct, duodenal papilla and gallbladder by inserting an endoscope through the mouth into the first part of the small intestine (duodenum). A smaller tube (catheter) is then inserted through the endoscope into the bile and pancreatic ducts. A colored substance (dye) is injected through the catheter for x-ray imaging.
- Upper GI endoscopyExamination of the upper gastrointestinal tract (esophagus, stomach and duodenum). During the exam, a small camera located at the tip of a flexible tube, is inserted through the mouth called a gastroscope
- CA 125This marker is a protein called MUC1, which is normally present in mucous membranes and protects the body from foreign factors. A high blood level of the CA 125 marker may indicate ovarian cancer, breast cancer, or other cancers.
- CA-125This marker is a protein called MUC1, which is normally present in mucous membranes and protects the body from foreign factors. A high blood level of the CA-125 marker may indicate ovarian cancer, breast cancer, or other cancers.
- Cytotoxic T lymphocyte antigen 4CTLA-4, Cytotoxic T lymphocyte antigen 4, is a protein found on cytotoxic T cells of the immune system, designed to control cells and prevent them from harming normal cells, thus preventing autoimmune and allergic diseases. In cancer patients, CTLA-4 expression causes cytotoxic T cells not to act against cancer cells. For further reading see the entry of “Immunosuppressive barrier”.
- CTLA-4CTLA-4, Cytotoxic T lymphocyte antigen 4, is a protein found on cytotoxic T cells of the immune system, designed to control cells and prevent them from harming normal cells, thus preventing autoimmune and allergic diseases. In cancer patients, CTLA-4 expression causes cytotoxic T cells not to act against cancer cells. For further reading see the entry of “Immunosuppressive barrier”.
- LibtayoLibtayo®, cemiplimab-rwlc, is anti cancer drug, a programmed death receptor-1 (PD-1) blocking antibody indicated for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC who are not candidates for curative surgery or curative radiation. Approved by FDA at Sept. 28, 2018 To Read More>>
- MekinistMekinist®, trametinib, is a kinase inhibitor indicated as a single agent for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test. MEKINIST is indicated, in combination with dabrafenib, for:
- The treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
- The adjuvant treatment of patients with melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test, and involvement of lymph node(s), following complete resection.
- The treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.
- The treatment of patients with locally advanced or metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation and with no satisfactory locoregional treatment options
- TafinlarTafinlar®, dabrafenib, is a kinase inhibitor indicated as a single agent for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test. Tafinlar is indicated, in combination with trametinib, for:
- Treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
- The adjuvant treatment of patients with melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test, and involvement of lymph node(s), following complete resection.
- The treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.
- The treatment of patients with locally advanced or metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation and with no satisfactory locoregional treatment options.
- ZelborafZelboraf®, vemurafenib, is a kinase inhibitor indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test. Zelboraf® is indicated for the treatment of patients with ErdheimChester Disease with BRAF V600 mutation
- ErivedgeErivedge®, vismodegib, is a hedgehog pathway inhibitor indicated for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery and who are not candidates for radiation To read more>>
- OdomzoOdomzo®, sonidegib, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (BCC) who are not amenable to curative surgery or radiation therapy The normal growth of cells is controlled by various chemical signals. In patients with basal cell carcinoma, changes occur to genes controlling a part of this process known as the “hedgehog pathway”. This switches on signals that make the cancer cells grow out of control. Odomzo works by blocking this process, stopping cancer cells from growing and making new cells. To read more>>
- CisplatinCisplatin is chemotherapy, anti cancer drug for infusion indicated as palliative therapy, to be employed either as a single agent or in established combination therapy with other chemotherapeutic agents in the following indications:
- Metastatic Testicular Tumors In established combination therapy with other approved chemotherapeutic agents, in patients with metastatic testicular tumors who have already received appropriate surgical and/or radiotherapeutic procedures.
- Metastatic Ovarian Tumors In established combination therapy with other approved chemotherapeutic agents, in patients with metastatic ovarian tumors who have already received appropriate surgical and/or radiotherapeutic procedures. An established combination consists of cisplatin and cyclophosphamide. Cisplatin, as a single agent, is indicated as secondary therapy in patients with metastatic ovarian tumors refractory to standard chemotherapy that have not previously received cisplatin therapy.
- Advanced Bladder Cancer Cisplatin is indicated as a single agent for patients with transitional cell bladder cancer, which is no longer amenable to local treatments such as surgery and/or radiotherapy
- HycamtinHycamtin®, topotecan, for Injection is a chemotherapy, anti cancer drug, a topoisomerase inhibitor indicated for:
- Metastatic ovary cancer after failure of initial or subsequent chemotherapy.
- Small cell lung cancer sensitive disease after failure of first-line chemotherapy.
- combination therapy with cisplatin for stage IV-B, recurrent, or persistent cervix cancer which is not amenable to curative treatment with surgery and/or radiation therapy.
- DoxorubicinDoxorubicin is chemotherapy anti cancer medication and been used successfully to produce regression in disseminated neoplastic conditions such as acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer To read more>>
- etoposideEtopophos®, etoposide a topoisomerase inhibitor indicated for the treatment of patients with:
- Refractory Testicular Tumors - Etopophos is indicated, in combination with other chemotherapeutic drugs, for treatment of patients with refractory testicular tumors.
- Small Cell Lung Cancer - Etopophos is indicated, in combination with cisplatin, for first line treatment of patients with small cell lung cancer.
- CTLA-4CTLA-4 is a protein found on cytotoxic T cells of the immune system, designed to control cells and prevent them from harming normal cells, thus preventing autoimmune and allergic diseases. In cancer patients, CTLA-4 expression causes cytotoxic T cells not to act against cancer cells. For further reading, see the entry of “Immunosuppressive barrier”.
- YervoyYervoy® (ipilimumab) is a human cytotoxic T-lymphocyte antigen 4 (CTLA-4)-blocking antibody indicated for:
- Treatment of unresectable or metastatic melanoma in adults and pediatric patients (12 years and older).
- Adjuvant treatment of patients with cutaneous melanoma with pathologic involvement of regional lymph nodes of more than 1 mm who have undergone complete resection, including total lymphadenectomy.
- Treatment of patients with intermediate or poor risk, previously untreated advanced renal cell carcinoma, in combination with nivolumab.
- Treatment of adult and pediatric patients 12 years of age and older with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, in combination with nivolumab. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.
- OpdivoOpdivo®, nivolumab, is anti cancer drug, a programmed death receptor-1 (PD-1) blocking antibody indicated for the treatment of:
- Unresectable or Metastatic Melanoma - Opdivo, as a single agent or in combination with ipilimumab, is indicated for the treatment of patients with unresectable or metastatic melanoma
- Adjuvant Treatment of Melanoma - Opdivo is indicated for the adjuvant treatment of patients with melanoma with involvement of lymph nodes or metastatic disease who have undergone complete resection
- Metastatic Non Small Cell Lung Cancer - Opdivo is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving Opdivo
- Small Cell Lung Cancer - Opdivo is indicated for the treatment of patients with metastatic small cell lung cancer (SCLC) with progression after platinum-based chemotherapy and at least one other line of therapy. This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.
- Advanced Renal Cell Carcinoma - Opdivo as a single agent is indicated for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy
- Opdivo, in combination with ipilimumab, is indicated for the treatment of patients with intermediate or poor risk, previously untreated advanced renal cell carcinoma (RCC)
- Classical Hodgkin Lymphoma - Opdivo is indicated for the treatment of adult patients with classical Hodgkin lymphoma (cHL) that has relapsed or progressed after: * autologous hematopoietic stem cell transplantation (HSCT) and brentuximab vedotin, or * 3 or more lines of systemic...
- CyramzaWhat Cyramza® is? Cyramza contains the active substance ramucirumab, which is a monoclonal antibody. This is a specialised protein that can recognise and attach to another protein found on blood vessels called ‘VEGF receptor 2’. This receptor is needed in the development of new blood vessels. To grow, cancer needs new blood vessels to develop. By attaching to ‘VEGF receptor 2’ and blocking it the medicine cuts off the blood supply to the cancer cells. What is this medicine intended for? Cyramza is a medicine for the treatment of cancer:
- Cyramza is given in combination with paclitaxel, for the treatment of advanced stomach cancer (or cancer of the junction between the oesophagus and the stomach) in adults whose disease has worsened after prior treatment with chemotherapy (platinum and fluoropyrimidine).
- Cyramza is given as a monotherapy for the treatment of advanced stomach cancer (or cancer of the junction between the oesophagus and the stomach) in adults whose disease has worsened after prior treatment with chemotherapy (platinum or fluoropyrimidine), for whom treatment of Cyramza in combination with paclitaxel is not suitable.
- Cyramza is given to treat metastatic colon or rectum cancer in adults, whose disease has worsened, on or after prior treatment with oxaliplatin, bevacizumab, and a fluoropyrimidine. This treatment is administered in combination with other medicines called “FOLFIRI chemotherapy”, including 5-fluorouracil, folinic acid, and irinotecan.
- Cyramza is given in combination with docetaxel, for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer whose disease has worsened after platinumbased chemotherapy
- Avastin
- HepatitisHepatitis is an inflammation of the liver. Viruses cause most cases of hepatitis. The type of hepatitisis named for the virus that causes it; for example,hepatitis A, hepatitis B or hepatitis C. Drug or alcohol use can also cause hepatitis.
- Hepatitis A - Acute disease in which patients usually recover, there is a vaccine for prevention
- Hepatitis B - chronic acute disease, which does not pass, and causes problems and complications in the liver. There is a vaccine for prevention
- Hepatitis C - a contagious liver disease that can be mild and transient or chronic and can cause liver damage such as liver cancer.
- BilirubinBilirubin is a substance that can cause jaundice. Liver dysfunction, gallbladder, bile ducts disorders can cause an increase in blood bilirubin levels. Blood tests examine the Total or Direct bilirubin values in order to detect suspected Hepatobiliary cancers, liver hepatitis, bile stones, metabolic diseases, alcoholism, and other diseases
- JaundiceJaundice is a disease in which yellow color appears in the eyes and skin. Due to a disease or infection, a substance called Bilirubin remains in the bloodstream and colors the skin and eyes. There are several types of jaundice, for example: Neonatal jaundice - yellowish discoloration of the white part of the eyes and skin in a newborn Adult Jaundice caused by:
- Viruses, including Hepatitis A, Hepatitis B and C, Epstein-Barr virus
- Common drugs
- Excessive alcohol consumption
- Autoimmune and/or metabolic disorders
- HepatobiliaryHepatobiliary system includes the liver, gallbladder, bile ducts, pancreas or bile.
- GemzarGemzar® is the commercial name of anti cancer drug - gemcitabine
- gemcitabineGemzar, gemcitabine, is a chemotherapy drug for infusion. Therapeutic indications are:
- Non Small Cell Lung Cancer: Gemcitabine is indicated for the palliative treatment of patients with locally advanced or metastatic non-small cell lung cancer.
- Breast cancer: Gemcitabine, in combination with paclitaxel, is indicated for the treatment of patients with unresectable, locally recurrent or metastatic breast cancer who have relapsed following adjuvant / neoadjuvant chemotherapy. Prior chemotherapy should have included an anthracycline unless clinically contraindicated.
- Pancreatic Cancer: Gemcitabine is indicated for the treatment of patients with locally advanced or metastatic adenocarcinoma of the pancreas and for patients with 5-FU refractory pancreatic cancer.
- Bladder Cancer: Gemcitabine is indicated for the treatment of patients with bladder cancer at the invasive stage.
- FluorouracilAdrucil®, Fluorouracil, 5FU, is is a chemotherapy drug, indicated for palliative management of carcinoma of the colon, rectum cancer, breast cancer, stomach cancer and pancreas cancer in selected patients considered incurable by surgery or other means. As leucovorin fluorouracil chemotherapy combination for cancer treatment
- TarcevaTarceva® is the commercial name of anti cancer drug - erlotinib.
- XelodaXaloda® is the commercial name of Capecitabine, a chemotherapy drug.
- EloxatinEloxatin® is the commercial name of Oxaliplatin, a chemotherapy drug.
- OxaliplatinEloxatin®, Oxaliplatin, is a platinum-based drug used in combination with infusional 5 fluorouracil /leucovorin, which is indicated for: • adjuvant treatment of stage III (Duke's C) colon cancer in patients who have undergone complete resection of the primary tumor. • treatment of advanced colorectal cancer. Oxaliplatin in combination with leucovorin, irinotecan and 5-fluorouracil is indicated for the first-line treatment of patients with metastatic pancreatic adenocarcinoma
- CamptosarCamptosar®, Campto®, Irinotecan, is is the commercial name of Oxaliplatin, a chemotherapy drug.
- CamptosarCamptosar®, Campto®, Irinotecan, is a chemotherapy, intravenous infusion, indicated for the treatment of patients with with: Metastatic colorectal cancer: 1. In combination with 5-fluorouracil and folinic acid in patients without prior chemotherapy for metastatic disease. 2. As a single agent in patients who have failed an established 5-fluorouracil containing treatment regimen. For the treatment of patients with small cell lung cancer, SCLC. For the treatment of patients with gastric cancer. Irinotecan in combination with leucovorin, oxaliplatin and 5-fluorouracil for the first-line treatment of patients with metastatic pancreatic adenocarcinoma
- Small Cell Lung CancerSmall Cell Lung Cancer, SCLC - This cancer constitutes approx. 15% of lung cancers and is considered to be particularly aggressive. Its source is in cells from the central region of the lung and connection was found with smoking habits and history. This cancer spreads rapidly and the major cause of most lung cancer cases is active and passive smoking. Other causes may be exposure to radon gas, asbestos, and lung cancer in a family member among other things; however, these are the minority of the cases. To read more>>
- LeucovorinA chemotherapy drug, indicated to diminish the toxicity and counteract the action of folic acid antagonists in cytotoxic therapy. As Leucovorin-Fluorouracil chemotherapy combination for cancer treatment.
- CytotoxicToxic. Chemotherapy can be cytotoxic, which is toxic to the body. In general, any substance may have a cytotoxic (toxic) effect, depending on dosage.
- Cytostatic medicationsMedications known as “cytostatic medications” stop the development of cancerous cells.
- EGFREpidermal Growth Factor Receptor, EGFR, is a receptor found on many cells that is the receptor of the EGF growth hormone. When EGFR binds to the EGFR receptor, there will be an increase in the EGFR level on the cancerous cell. to be involved in the growth and spread of cancerous cells. Tarceva®, erlotinib, is a drug potently inhibits the intracellular phosphorylation of EGFR.
- Epidermal Growth Factor ReceptorEpidermal Growth Factor Receptor, EGFR, is a receptor found on many cells that is the receptor of the EGF growth hormone. When EGFR binds to the EGFR receptor, there will be an increase in the EGFR level on the cancerous cell. to be involved in the growth and spread of cancerous cells. Tarceva®, erlotinib, is a drug potently inhibits the intracellular phosphorylation of EGFR.
- ErlotinibTarceva® is a film-coated tablet contains erlotinib. Erlotinib is an epidermal growth factor receptor (EGFR also known as HER1) tyrosine kinase inhibitor. Erlotinib potently inhibits the intracellular phosphorylation of EGFR. EGFR is expressed on the cell surface of normal cells and cancer cells. Therapeutic indications: Non Small Cell Lung Cancer (NSCLC)
- Tarceva is indicated for the first-line treatment of patients with locally advanced or metastatic non small cell lung cancer (NSCLC) with EGFR activating mutations.
- Tarceva is indicated for switch maintenance treatment in patients with locally advanced or metastatic non small cell lung cancer (NSCLC) with EGFR activating mutations and stable disease after first-line chemotherapy.
- Tarceva is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen.
- Tarceva is indicated in combination with gemcitabine for the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
- CapecitabineXeloda®, Capecitabine is a chemotherapy, one of a group of medications known as "cytostatic medications" that stop the development of cancerous cells. For adjuvant Colon Cancer: Capecitabine is indicated for the adjuvant treatment of patients following surgery of stage III (Dukes stage C) colon cancer. Colorectal Cancer: Capecitabine is indicated for the treatment of patients with advanced or metastatic colorectal cancer. Advanced gastric cancer: Capecitabine is indicated for first line treatment of advanced gastric cancer in combination with chemotherapy. Breast Cancer Combination Therapy: Capecitabine in combination with docetaxel is indicated for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy. Breast Cancer Monotherapy: Capecitabine is also indicated for the treatment of advanced or metastatic breast cancer after failure of standard therapy including a taxane unless therapy with a taxane is clinically contraindicated. The medication can be taken by itself or in combination with other medications
- Compassionate DrugA way to provide medical care to a patient who is not eligible for treatment by participating in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. This extended approach allows the patient to receive promising anti-cancer treatments that have not yet been approved, when no other treatment is possible
- NSCLCNon Small Cell Lung Cancer, NSCLC. A group of lung cancers that are Non Small Cell type. Treatment and prognosis are similar to all cancers in this group. This cancer group constitutes for about 85% of all lung cancers.
- Non Small Cell Lung CancerNon Small Cell Lung Cancer, NSCLC. A group of lung cancers that are Non Small Cell type. Treatment and prognosis are similar to all cancers in this group. This cancer group constitutes for about 85% of all lung cancers.
- AbraxaneAbraxane, Nab-Paclitaxel, is Taxol® drug (chemotherapy) link to a protein called Albumin. As a monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline containing therapy is not indicated. Abraxane in combination with gemcitabine is indicated for the first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas. Abraxane in combination with carboplatin is indicated for the first-line treatment of non small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy.
- Clinical trialStudy, also called “Clinical Trial” on human beings are necessary in order to collect information mainly on the safety and efficacy of an innovative treatment. Usually a clinical trial consists of three phases. The first, second, and third phases are usually different from each other in the number of people participating in each. In the third phase, the number of subjects is the largest. A clinical trial can be stopped at each phase.
- Compassionate drugsA way to provide medical care to a patient who is not eligible for treatment by participating in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. This extended approach allows the patient to receive promising anti-cancer treatments that have not yet been approved, when no other treatment is possible.
- Clinical TrialsStudies, also called “Clinical Trials” on human beings are necessary in order to collect information mainly on the safety and efficacy of an innovative treatment. Usually a clinical trial consists of three phases. The first, second, and third phases are usually different from each other in the number of people participating in each. In the third phase, the number of subjects is the largest. A clinical trial can be stopped at each phase.
- Bladder CancerA condition in which bladder cells in the body divide uncontrollably.
- GardasilThe Gardasil® vaccine is used against the Papilloma virus with the goal to prevent infection with women, and the vaccine itself is given to both girls and boys and women up to age 45. One of the main causes for cervical cancer is the Human Papilloma Virus, HPV, which causes warts on the female genitalia.
- Pap testCervical cancer is mostly diagnosed by laboratory examination of the cervical surface also called “Pap test” or Pap Smear”. Early detection affects the disease treatment plan and also treatment success.
- Papilloma VirusOne of the main causes of Cervical cancer is the Human Papilloma Virus, HPV, which causes warts on the female genitalia. The Gardasil® vaccine is used against the Papilloma virus with the goal to prevent infection with women, and the vaccine itself is given to both girls and boys and women up to age 45.
- Small cell carcinoma of the ovaryIs an extremely rare ovarian cancer and it is not certain whether the cells in SCCO are formed from. Two types in this group:
- Hypercalcemic
- Pulmonary
- Stromal cell ovarian cancerArises from connective tissue cells and is very rare. The most common types in this group are:
- Granulosa-theca tumors, GCTs
- Sertoli-Leydig cell tumors
- Germ Cell ovarian cancerStarts from the reproductive cells of the ovaries and is rare. Four major types of germ-cell ovarian cancer:
- Dysgermnimoma
- Endodermal sinus tumor, EST
- Teratoma
- Mixed germ cell tumor, GCT
- Embryonal carcinoma
- Polyembryoma
- Choriocarcinoma
- Epithelial Ovarian CancerIts origin is the epithelial cells coating the ovary. It is the most common ovarian cancer, about 90% of cases. Fallopian Tube Cancer and Primary Peritoneal Cancer are also types of epithelial ovarian cancer. Five major types of epithelial ovarian cancer
- High-Grade Serous Carcinoma which comprises about 70% of all ovarian carcinomas
- Clear-Cell Carcinoma which comprises about 10% of all ovarian carcinomas
- Endometrioid carcinoma which comprises about 10% of all ovarian carcinomas
- Low-Grade serous carcinoma which comprises less than 5% of all ovarian carcinomas
- Mucinous carcinoma which comprises less than 5% of all ovarian carcinomas
- Triple positive breast cancerThe tumor includes receptors for HER2, Estrogen and Progesterone. Considered to be a curable cancer.
- Hormone positive breast cancerThe cancer tumor contains receptors to Estrogen and Progesterone. It is considered to be the cancer type that has particularly high therapeutic success.
- HER2 positive Breast CancerHER2 is a protein that naturally occurs on shells of normal cells of our bodies. In approx. 20% of breast cancer cases, this protein appears in excess. At the present, a number of biological drugs exist that bind to this protein and prevent its proliferation.
- Pancreas headTumor in the pancreas head – mostly expressed with jaundice and inflammation of the pancreas parenchyma due to blockages it creates in the biliary and pancreatic ducts
- OptuneTTF (Tumor Treating Fields), Optune® involve positioning electrodes directly on the patient’s skull. Electrical fields are directed to the brain tumor. In this way, the electric fields do not damage healthy cells but definitely disrupt the process of cancerous cells dividing and multiplying, and eventually brings about the eradication of cancerous cells. This treatment has been proven to hold a clear advantage when patients are simultaneously treated with electrodes and chemotherapy. The Optune® device constitutes a breakthrough option in this field, developed by an Israeli company Novocure®.
- Bone Marrow TransplantationThis treatment approach can be very efficacious in blood cancer patients, such as Leukemia and Lymphoma. White or red blood cells which were destroyed by chemotherapy or radiation, are removed from the patient’s body, strengthened in the lab and infused back to the patient’s body.
- AdjuvantPost-surgery treatment, also known as ‘Adjuvant’ - This treatment seeks to cure and prevent the appearance of metastases or recurrence of the tumor.
- NeoadjuvantTreatment prior to surgery is known as ‘Neoadjuvant’ - Usually this stage of treatment will involve chemotherapy and/or radiotherapy intended to reduce the tumor’s size and improve the success of surgery.
- Basal cell carcinomaSourced in the skin’s basal cells found in the layer beneath squamous cells, this type of cancer is considered not aggressive since generally it does not metastasize.
- Skin Cancer Squamous Cell CarcinomaBegins in the squamous cells, flat cells with the appearance of fish scales and found on the external layer of skin, or epidermis. It develops slowly and is easy to treat if diagnosed early. Late diagnosis, however, may lead to its spread to adjacent membranes, lymph nodes or bones, making treatment more difficult.
- Skin CancerSkin cancer is currently the most common type of cancer. Its incidence has strongly risen over the past few decades, now accounting for one in every three newly diagnosed cases of cancer worldwide.
- Gliadel®Gliadel® Wafer is carmustine implant that is indicated for patients with newly diagnosed high-grade malignant glioma as an adjunct to surgery and radiation. Gliadel® Wafer is also indicated in patients with recurrent glioblastoma multiforme as an adjunct to surgery. The implant It is placed on the area in the brain during operation. Since the implant is biodegradable, there is no need to remove it in a repeat surgical procedure.
- TEMODAR®TEMODAR® contains a medicine called temozolomide. This medicine is an antitumour agent for the treatment of specific forms of brain tumours. TEMODAR® belongs to a group of medicines called cytotoxic or chemotherapy medicines. Therapeutic group: Antineoplastic preparation. TEMODAR® capsules are indicated for the treatment of: 1. Adult patients suffering from newly diagnosed glioblastoma multiforme in a combination treatment with radiation and subsequently as monotherapy treatment; 2. Children above the age of 3 years, adolescents and adults suffering from malignant glioma such as glioblastoma multiforme or anaplastic astrocytoma (specific forms of brain tumours), showing recurrence or progression after standard therapy; 3. TEMODAR® capsules are also indicated as first line treatment for adult patients with advanced metastatic malignant melanoma. To read more>>
- Solid TumorsTumor that are developed in a tissue, such as breast cancer, colon cancer, Gastric Cancer (in compare to not visible, such as, leukemia and these are called “Hematological cancers” as they developed in the blood formation path).
- MenopauseMenopause is a normal condition that all women experience as they age. It is divided into three stages: (i) Perimenopause - occurs several years before the Menopause and begins when the ovaries gradually produce less estrogen. In the last two years of this process, when estrogen levels are low, symptoms of hot flashes and night sweats begin. (ii) Menopause - the point at which the ovaries stop releasing eggs and menstruation ends. (iii) Post-menopause - the period after menopause and symptoms of premenopause began to ease. This is a consideration when making a therapeutic decision in women with cancer.
- PD-L1This protein is at a high level in various cancers. When PD-L1 on a cancer cell binds to the PD-1 protein, cytotoxic T cells (cytotoxic cells) - the cytotoxic T cells do not kill the tumor. This is the mechanism of "escape" of cancer from the immune system. For further reading, see the value “immunosuppressive barrier”.
- BRCA1A protein responsible for DNA repair. When BRCA1 or BRCA2 genes are damaged (e.g. mutation) the chances of getting breast cancer increases. BRCA1, BRCA2 = BReast CAncer gene
- BRCA1A protein responsible for DNA repair. When BRCA1 or BRCA2 genes are damaged (e.g. mutation) the chances of getting breast cancer increases. BRCA1, BRCA2 = BReast CAncer gene
- BRCA1, BRCA2A protein responsible for DNA repair. When BRCA1 or BRCA2 genes are damaged (e.g. mutation) the chances of getting breast cancer increases. BRCA1, BRCA2 = BReast CAncer gene
- Ewing’s sarcomaA type of cancer that begins in the bones or soft tissues of the body commonly is diagnose in young adults.
- Breast CancerA condition in which breast cells in the body divide uncontrollably. The disease is classified according to the breast cells from which it develops.
- CannabisThe leaves and flowers in their dry form of the cannabis sativa and cannabis indica plants. Cannabis contains chemicals called cannabinoids, the most famous of which are THC, CBD and CBN. Marijuana is given to cancer patients mainly to stimulate appetite, increase weight, reduce nausea, relieve pain and more.
- GlioblastomaGlioblastoma Multiforme, or GBM, is a type of cancer which originates in the brain and made of brain cells known as “gliomas.”
- GBMGlioblastoma Multiforme, or GBM, is a type of cancer which originates in the brain and made of brain cells known as “gliomas.”
- ESMOEuropean Society for Medical Oncology is the leading professional organisation for medical oncology with 20,000 members representing oncology professionals from over 150 countries worldwide.
- HER2Human Epidermal Growth Factor Receptor 2, HER2, HER2/neu - A protein involved in cellular processes such as angiogenesis, differentiation, growth, and more. Her2 can be found in high levels in breast, ovarian, bladder, pancreas and stomach cancers and cause cancer cells grow faster and spread in the body. A number of biological drugs are available today which binds to this protein and by that prevent the cancer from growing.
- CAR-T
- Colorectal CancerA condition in which intestine or rectum cells divide uncontrollably. Often this cancer starts with a growth of a polyp in the intestine or in the rectum. Locating and removing polyps may prevent the appearance of colon cancer and this is the reason for the importance of early detection. Also known as “Bowel cancer” or “Colon cancer”
- Colon CancerA condition in which intestine cells divide uncontrollably. Often this cancer starts with a growth of a polyp in the intestine. Locating and removing polyps may prevent the appearance of colon cancer and this is the reason for the importance of early detection. Also known as “Bowel cancer” or “Colon cancer”
- CannabinoidsThe leaves and flowers in their dry form of the cannabis sativa and cannabis indica plants. Cannabis contains chemicals called cannabinoids, the most famous of which are THC, CBD and CBN. Marijuana is given to cancer patients mainly to stimulate appetite, increase weight, reduce nausea, relieve pain and more.
- NCIThe National Cancer Institute is is federal agency in the US Department of Health responsible for research and training of cancer disease
- FDA – Food and Drug AdministrationA US federal agency that aims to protect public health by ensuring that food, cosmetics and nutritional supplements are safe to use and honestly labeled.The FDA also ensures that medicines, medical devices, and equipment are safe and effective, as well as clinical studies after examining all aspects Relating to human health and was convinced that research could promote the proposed medicine for patients
- Food and Drug AdministrationFood and Drug Administration is a US federal agency that aims to protect public health by ensuring that food, cosmetics and nutritional supplements are safe to use and honestly labeled.The FDA also ensures that medicines, medical devices, and equipment are safe and effective, as well as clinical studies after examining all aspects Relating to human health and was convinced that research could promote the proposed medicine for patients
- Cervical cancerCervical cancer is the sixth cancer prevalent among women. One of the main causes for the disease is the Human Papilloma Virus, HPV, which causes warts on the female genitalia. The Gardasil® vaccine is used against the Papilloma virus with the goal to prevent infection with women, and the vaccine itself is given to both girls and boys and women up to age 45.
- Stage IVAn advanced stage in which the tumor spreads and sends metastases to distant organs
- Stage 4An advanced stage in which the tumor spreads and sends metastases to distant organs
- Pancreatic cancerPancreatic cancer occurs when cancer cells develop in the tissues from which the pancreas is made. This type of cancer is aggressive, since most of the patients are diagnosed in an advanced stage, where the disease is considered incurable, for the most part. This type of cancer is hard to diagnose early since its symptoms do not usually appear in early stages. In many cases until the patient is diagnosed with a pancreatic cancer there are already metastases elsewhere in the body (stage 4 metastatic pancreatic cancer).
- Gastric cancerGastric cancer, also called “Stomach cancer”, starts when some of the cells constituting the inner part of the stomach start growing and proliferating without control. This abnormal growth creates a tumor that is cancerous. Usually gastric cancer grows slowly, along a course of many years.
- Pancreatic cancerPancreatic cancer occurs when cancer cells develop in the tissues from which the pancreas is made. This type of cancer is aggressive, since most of the patients are diagnosed in an advanced stage, where the disease is considered incurable, for the most part. This type of cancer is hard to diagnose early since its symptoms do not usually appear in early stages. In many cases until the patient is diagnosed with a pancreatic cancer there are already metastases elsewhere in the body (stage 4 metastatic pancreatic cancer).
- Whipple procedure pancreaticoduodenectomyPancreas head removing surgery, together with a part of the small intestine (the duodenum), gallbladder and the biliary and lymph ducts. The surgery is possible when the tumor is small in size and has not yet metastasized. When the tumor is located in the pancreas body or tail, a resection of this part of the pancreas will be performed.
- Cerebral Spinal Fluid, CSFA clear, colorless liquid that envelops the brain and spinal cord
- Generic DrugGeneric drugs are copies of other drugs that are already in the market. Their use, effects, side effects, management pathway, risks, safety and efficacy are like the original medicine. In other words, their pharmacological effect is similar to the original drugs. It is important to note that the therapeutic effect of a generic drug is not always exactly the same as the therapeutic effect of the original drug.
- BiologicsClass of medications that include immunotherapy, monoclonal antibodies, cancer growth inhibitors and vaccines. Herceptin® , Avastin®, Lynparza® and Keytruda® are biological drugs.
- Thrombocyt
- Pleural EffusionBuild-up of excess fluid between the thin layers of the tissue surrounding the lung and chest cavity.
- Hand and foot syndrome(HFS)Pain, swelling, numbness, tingling, or redness of the hands or feet. Sometimes it happens as a side effect of certain anti-cancer drugs. Also called foot syndromeת or Palmar Plantar Erythrodysesthesia
- Adverse Effect, Side EffectAdverse Event, also called “Side Efeect” is an undesirable phenomenon that is caused to a patient as a result of treatment.
- Immune ResponseThe body's response to foreign substances entering it, for example bacteria. The body identifies antigens molecules molecules (eg proteins, sugars) belonging to the invading organism. The immune system, for example, can identify proteins on the virus's envelope and act against them by producing antibodies. In cancer, cancer cells can express very high and abnormal levels of a particular molecule, which is also called antigen (although it is not foreign, it is part of the body). The immune system can identify this aberration and initiate an immune response. For example, breast cancer cells may express higher amounts than the normal HER2 molecule, which stimulates the immune system to respond to the HER2 overexpressing cells. Cancer cells develop various mechanisms that help them avoid the immune system.
- Complete ResponseComplete reduction or disappearance of cancer symptoms. In partial remission some of the symptoms disappear as opposed to a complete remission in which all symptoms disappear, although the cancerous tumor may still be present in the body.
- Partial ResponseA decrease in the size of the tumor in response to treatment
- Objective ResponseA measurable response. For example, a response to chemotherapy.
- White Blood CellWBC - A type of blood cell produced in the bone marrow and found in the blood. Red blood cells contain a protein called hemoglobin, which leads oxygen from the lungs to all parts of the body. Checking the number of red blood cells in a blood is usually performed in order to diagnose physiological conditions such as anemia, dehydration, malnutrition, leukemia, and more. It is also called erythrocyte.
- Red Blood Cell, RBCA type of blood cell produced in the bone marrow and found in the blood. Red blood cells contain a protein called hemoglobin, which leads oxygen from the lungs to all parts of the body. Checking the number of red blood cells in a blood is usually performed in order to diagnose physiological conditions such as anemia, dehydration, malnutrition, leukemia, and more. It is also called erythrocyte.
- BenignNot cancerous. The cells in a benign tumor do not damage the tissue in which they are present and do not metastasize.
- Response RateThe percentage of patients in whom the cancer has decreased or disappeared after treatment.
- ESRBlood test that measures how far red blood cells travel in one hour in a blood sample as they settle into the bottom of the tube. The rate of ESR increases with inflammation, infection, and also in cancer. Also called “Sedimentation Rate”
- Survival RateThe percent of people who survive a disease such as cancer for a specified amount of time
- Negative MarginNo Margin
- Positive Margins
- Margin (Surgical Margin)The border of the tumor tissue that is surgically removed. The margins are considered negative when cancer cells are not identified. The margins are considered positive when cancer cells are detected, which means that not all of the tumor has been removed and there is residual tumor.
- Pathological FractureBone fracture caused by disease. Patients with bone metastases are particularly prone to pathological fractures, since these tumors tend to cause bone destruction. Sometimes the bone is broken before the patient is diagnosed with cancer.
- RefractoryWhich does not respond to treatment. Cancer that does not respond to treatment may be resistant at the beginning of treatment or it may become resistant during treatment.
- Complementary MedicineTraditional holistic medicine originating from ancient cultures. This medicine focuses on strengthening the connection between body and mind. The conventional health system has integrated complementary therapies such as homeopathy, energetic healing, acupuncture, herbal medicine and more.
- Irreversible ToxicitySide effects from treatment that do not disappear.
- ResectableWhich can be surgically removed
- RemissionComplete reduction or disappearance of cancer symptoms. In partial remission some of the symptoms disappear as opposed to a complete remission in which all symptoms disappear, although the cancerous tumor may still be present in the body.
- ResidualRemaining after the greater part or quantity has gone. In cancer, residual cancer cells are cells left after attempts to remove the cancer by surgery, radiation etc. Residual
- Free RadicalFree radicals are un unstable molecules that are usually produced in the bodies during the process of cell metabolism. Free radicals can accumulate in cells and damage other molecules, such as DNA, lipids, and proteins. The dammages caused by free radicals increases the risk of cancer and other diseases. Free radicals can also be absorbed by the human body from the environment. Antioxidants minimze the damage caused by free radicals.
- ROS1A protein involved in gene rearrangement. Different cancers have mutations in ROS1.
- Radiotherapy
What is Radiotherapy?
If you have diagnosed with cancer radiation may be considered as part of the therapeutic protocol. The use of high-energy radiation from X-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and tumor that developed in your body.What types of radiation exist?
There are 2 types of radiation:- External radiation - The radiation is given by an external device emitted by the emitter near the affected area.
- Internal radiation, brachytherapy - A radioactive substance is inserted with a tube into the body near the tumor.
When the oncologist will consider to the usage of radiation for my condition?
In cases which only the tumor and some surrounding tissue is removed it is not common to add radiation. Radiation will sometimes be considered to ensure that no cancer cells remain that were not seen during surgery but remained in the area. In cases of partial removal, radiation will be used to kill cancer cells remaining in the post- operation zone and to slow down the growth rate of the remaining tumor. Radiation will sometimes be combined with chemotherapy - Chemoradiotherapy Good Luck! - RhabdomyoscomaSarcoma, a cancer of muscle tissue.
- Sentinel lymph nodeThe first lymph node to which the cancerous tumor drains. The cancer cells in the tumor can spread to another tissue through the lymphatic system, which is made up of tubes and lymph nodes (“Lymphatic System”).
- NodeA small amount of cells forming circular tissue.
- Squamous Cell CarcinomaCancer that begins with squamous cells that are flat cells that look like fish scales. The dandruff cells are found in the tissue that forms the surface of the skin, in the hollow organ wall (e.g. intestines, rectum, stomach), and the lining of the digestive system. This cancer appears in the anus, cervix, head and neck and vagina
- Leptomeningeal CancerWhen the cancer cells spread from the original (primary) tumor to the brain membrane (thin layers of tissue covering the brain and spinal cord). It can occur in many types of cancer, but it is most common in melanoma, breast cancer, lung cancer, gastric cancer and colon cancer. Cancer can cause meningitis.
- Epithelial Overian CarcinomaMost common ovarian cancer, about 90% of all ovarian cancers. This cancer originates in the layer of epithelium in the ovary walls.
- Carcinoma In-situA cancerous tumor originating from epithelial cells. The tumor is still local and has not metastasized.
- CarcinomaA cancerous tumor originating from epithelial cells. Cells in carcinoma have an ability to penetrate the healthy tissue and produce metastases.
- CarcinogenA substance that raises the risk of cancer.
- External Beam Radiation, EBTExternal radiation therapy (EBT) in which high-energy X-rays is provided to the patient's tumor. This is in contrast to brachytherapy (see value) where the source of radiation is introduced into the tumor area, for example with a catheter
- CreatinineCreatinine levels are measured to monitor renal function. Excreted in the urine.
- AlopeciaLack of hair from places in the body where there is usually hair. Hair loss can be caused by anti-cancer treatments.
- CardiotoxicityDamage to the heart or function that can be caused, for example, by exposure to toxic substances such as chemotherapy, immunotherapy, or radiation
- CardialRelated to the heart.
- ReceptorA condition in which there is one or more diseases in addition to the main disease. Also called "background diseases".
- Comorbidity
- ColostomyAn operation usually performed after rectal removal (rectum) or the lower part of the colon. During the operation, a portion of the colon is brought to the abdominal wall and creates an artificial opening (stoma) that allows the stool to be emptied into a skin-tight bag temporarily or permanently.
- ColonoscopyA test used for early detection of colon cancer. During the test, a colonoscope (thin tube with a camera) is inserted through the anus, rectum and colon.
- Third Line TreatmentThe treatment series given to the patient after the second treatment line ("Second Line") stopped working.
- Second Line TreatmentThe treatment series given to the patient after the first series ("First Line") stopped working.
- First Line treatmentThe first treatment series given to the patient after diagnosis. Called "First Line".
- Control groupIn a clinical trial, it is the group that does not accept the new treatment being studied, but the standard treatment at the time. This group is compared to the group receiving the new treatment to see if the new treatment is more effective than the standard treatment. The control group can receive a placebo. It is important to note that not every clinical trial has a control group
- PeritoneumThe membrane lining the walls of the abdominal cavity
- cystoscopyExamination of the bladder and urethra using a cytoscope inserted into the urethra. A cystoscope is a thin tube-like device with light and a viewable lens. A biopsy can be used with the help of the cytoscope. The test has many uses, including checking the presence of cancerous tumors and monitoring.
- CytokineProteins which are secreted in the body and immune system cells. Some cytokines stimulate the immune system and others slow it down. Cytokines have many uses, and they can help the body fight cancer, infections and other diseases. Examples of cytokines are: interleukins and interferons. Today there are about 130 cytokines known.
- Cytokine
- CytologyCell research using a biopsy microscope or body fluids such as urine
- PathologistA doctor who identifies diseases by examining cells and tissues under a microscope
- ParenteralInserting a drug into the body outside the digestive system: Intravenous IV injections, intramuscular (IM), and subcutaneous (subcortical) subcutaneous administration.
- PharmacologyA field that deals with the effect of a drug on the body. The field also focuses on research on how the body copes with the drug, for example, what dosage of the drug in the blood, and how long the body is cleaned of the drug and more.
- PharmacogeneticsA field that studies the effect of a person's genes on how he or she responds to drugs.
- PeritoneumThe membrane lining the walls of the abdominal cavity
- ProphylacticPreventive. Prophylactic treatment is a preventative treatment, a protective treatment
- Progesteron Receptor Negative, PR-Tumor cells containing a low amount of progesterone receptor.
- Progesteron Receptor Positive, PR+Describes tumor cells in which a high amount of progesterone receptor binds to the progesterone hormone. Usually these cells will stop growing when patients with hormones block the progesterone binding to its receptor. Also called PR +.
- ProgesteronA hormone produced by the body and plays a role in the menstrual cycle and pregnancy. There are breast tumors that overreact to the progesterone receptor and therefore these tumors depend on this hormone to grow.
- PrognosisThe course of the disease, the chance of recovery or the recurrence of the disease.
- PerimenopauseDuring Menopause, Perimenopause - occurs several years before the Menopause and begins when the ovaries gradually produce less estrogen. In the last two years of this process, when estrogen levels are low, symptoms of hot flashes and night sweats begin
- Venous thrombosis, VTBlood clot formation in the veins..
- ThrombosisBlood clot formation in blood vessels.
- PlaceboA substance or treatment of no intended therapeutic value. Common placebos include sugar pills), saline injections, sham surgery, and other.
- PETA radioactive substance is injected into the subject (e.g., radioactive sugar called FDG) and enters tissues with high sugar intake. Cancerous tumors consume the radioactive material.
- Leptomeningeal metastase, LMWhen cancer cells from the primary tumor spread to the meninges.
- PET CTA test that involves a CT scan and a PET test to diagnose cancerous tumors, but it also has other uses.
- Positron Emission Tomography, PETA test that involves a CT scan and a PET test to diagnose cancerous tumors, but it also has other uses. CT scan - see “CT” value. PET testing - A radioactive substance is injected into the subject (e.g., radioactive sugar called FDG) and enters tissues with high sugar intake. Cancerous tumors consume the radioactive material.
- ColostomyAn operation usually performed after rectal removal (rectum) or the lower part of the colon. During the operation, a portion of the colon is brought to the abdominal wall and creates an artificial opening (stoma) that allows the stool to be emptied into a skin-tight bag temporarily or permanently.
- PD-1A protein found on cytotoxic T cells that kill other cells. When PD-1 on T cells binds to a protein called PD-L1 on cancer cells, the cytotoxic T cells do not attack the tumor. It is an escape mechanism of cancer from the immune system. T cells are part of the immune system. For further reading, see the value “immunosuppressive barrier”.
- FatigueExhaustion
- Post menopausePost menopause - the period after menopause and symptoms of Perimenopause began to ease. This is a consideration when making a therapeutic decision in women with cancer.
- PostoperativePost-surgery
- PolypectomySurgery to remove polyps.
- Familial Adenomatous Polyposis, FAPA hereditary condition in which many polyps (see polyp value) are grown on the inner walls of the colon and rectum. Polyps can become cancerous. This condition increases the risk of developing colon cancer.
- PolypAccumulated cells protrude into the gastrointestinal tract and respiratory tract.
- Palliative
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- Poly ADP-ribose polymerase, PARPA protein in a cell that participates in processes such as DNA repair and cell death. Today, PARP inhibitors are used as an anti-cancer treatment.
- Resilience, ResistanceDoes not respond to treatment. Cancer that does not respond to treatment may be resistant at the beginning of treatment or it may become resistant during treatment.
- Intermittent InfusionInfusion of volume of liquid containing drug or nutrients over a specified period of time at preset intervals. The infusion stops until the next dose.
- Continuous infusion
- Secondary CancerA term used to describe cancer that has spread (metastases) from where it started to another part of the body. For example, cancer cells may spread from the intestines (primary cancer) to form new tumors in the liver (secondary cancer).
- Inflammatory breast cancerA type of breast cancer in which the breast looks red, bloated and feels warm. Peau d'orange-like appearance. The redness and warmth occur because the cancer cells block the lymphatic vessels in the skin.
- Small Cell Lung Cancer, SCLCCancer cells look small in the shape of an ellipse when viewed under a microscope.
- Head and Neck CancerA cancer located in the head or neck area but not in the brain, i.e. in the nasal cavity, sinuses, lips, mouth, salivary glands or throat (voice box).
- Peritoneal CancerPeritoneal cancer, peritoneum. Peritoneal - the membrane lining the walls of the abdominal cavity.
- Invasive Cancer Infiltrating CancerA cancer that grows beyond the tissue from which it was originated and penetrates into nearby healthy tissues.
- Locally Advanced CancerA cancer that has spread to the tissue adjacent to the tissue from which it was originated or to the lymph nodes
- Local CancerA tumor which has not yet spread.
- Cancer of Unknown Primary – CUPA condition in which the metastases can be identified but the primary tumor from which they have spread cannot be identified.
- Familial CancerCancer is seen in families more often than was randomly expected (coincidence). This cancer often occurs at a young age, and may indicate the presence of a genetic mutation that increases the risk of cancer. It also constitutes a sign of environmental factors affecting life in a common environment
- Lobular Carcinoma In-Situ, LCISLocal growth (without metastasis) located in the milk production glands.
- Recurrent Cancer
- Metastatic CancerA condition in which the primary tumor spreads to various organs in the body.
- CancerA condition in which cells in the body divide uncontrollably.
- Screening MammogramX-ray examination of breasts to prevent breast cancer in the absence of disease symptoms.
- ScreeningScreenings scan for disease presence when there are still no symptoms to diagnose diseases at an early stage and increase the chance of cure. Breast cancer, colonoscopy, PAP and HPV (cervical cancer) are examples of Screening tests. Genetic testing to examine a person's risk of developing hereditary disease is also a type of screening, for example, testing mutations in the BRCA gene for early detection or preventing the development of breast cancer
- Bilateral cancerCancer that appears in two pairs of organs simultaneously such as breasts, ovaries, eyes, lungs, etc.
- ScreeningScreenings scan for disease presence when there are still no symptoms to diagnose diseases at an early stage and increase the chance of cure. Breast cancer, colonoscopy, PAP and HPV (cervical cancer) are examples of Screening tests. Genetic testing to examine a person's risk of developing hereditary disease is also a type of screening, for example, testing mutations in the BRCA gene for early detection or preventing the development of breast cancer
- Squamous Cell SarcinomaCancer that begins with squamous cells that are flat cells that look like fish scales. The dandruff cells are found in the tissue that forms the surface of the skin, in the hollow organ wall (e.g. intestines, rectum, stomach), and the lining of the digestive system. This cancer appears in the anus, cervix, head and neck and vagina.
- Whole Blood CountA test in which the number of red blood cells, white blood cells and platelets in the blood is counted. The amount of hemoglobin (a protein in a red blood cell that binds oxygen) and the hematocrit (the volume of red blood cells relative to the total volume of the blood sample, measured as a percentage) is also measured.
- MarkerBiomarker in the blood. Examples of markers: CA-125 for ovarian cancer and CA-72-4 for adenocarcinomas of the gastrointestinal tract.
- SystemicTreatment that comes to all systems and organs in the body. Chemotherapy is systemic therapy. It affects normal dividing cells, not just cancer cells, and hence the many side effects associated with this type of treatment.
- StomaAn incision in the inner area of the body to the outside. For example, in Stomatomy, the intestines are brought from the anus to the abdominal wall to which the bag connects the intestinal secretions and requires a daily replacement. This bag is not visible and not detectable to an outside observer.
- SymptomSymptom. A physical or mental problem that a person experiences which may indicate illness. Symptoms cannot always be seen and measured in medical tests. Examples of symptoms are headaches, coughing, difficulty walking, fatigue and more.
- Stage/StagingEvaluations and measures to assess the size and extent of the spread of the cancer in order to plan the best treatment. The patient is usually assessed according to a system that quantifies the cancer by its size and if metastases are formed in various organs from the original tumor.
- SuppressorGenes that slow cell division participate in the process of correcting DNA errors, or that signal the cell do dies. When tumor suppressor genes fail to function properly, cells can get out of control and become cancerous.
- somatotropinA protein produced and secreted by the pituitary gland that is responsible for controlling body growth and glucose and gat metabolism.
- Karnofsky Performance Status, KPSA method scaled from 0 to 100 to assess the functioning and ability of cancer patients to perform normal tasks. For example, this scale can be used to determine the patient's prognosis or to decide whether to offer treatment or to recommend a clinical trial.
- Lower GI SeriesA series of X-rays of the colon after barium enema.
- Radical MesectomyBreast cancer surgery where the breast, chest muscles, and all the lymph nodes under the arm are removed. Radical excision is performed only when the tumor has spread to the chest muscles
- MastectomyComplete removal of the breast
- Breast-conserving Surgery (Lumpectomy)Surgical removal only of breast tumor and its margins. This is in contrast to complete mastectomy (a mastectomy)
- Hyperthermic Intraperitoneal Chemotherapy, HIPECAn procedure in which chemotherapy is administered directly to the abdominal cavity during surgery. This treatment can be beneficial to patients with primary tumors, for example in the ovaries and intestines that have metastasized to the lining of the stomach.
- Controlled Clinical TrialClinical trial including a comparison group (control group). The control group may receive placebo, other treatment, or no treatment at all.
- Cerebral Spinal Fluid, CSF
- AntibodyProteins that bind specifically to antigens (molecules identified by the immune system). For example, an antibody called Trastuzumab (Herceptin®) identifies the HER2 antigen, which is often found at a high level on the outer side of the surface of cancer cells.
- NeoplasmThe mass of cells which grows abnormally. This mass may be benign (non-cancerous), or malignant (cancer). Also called "tumor"
- NeoadjuvantPrimary treatment of cancer (chemotherapy, radiation, hormonal, etc.) which can be given prior to a major procedure or treatment, such as surgery.
- MRIA method of imaging based on radio waves and a magnet. The images produced by this method can show the difference between normal tissues and affected tissues
- Mammography
What is a mammogram?
Mammography is the use of low energy X-rays to detect suspicious breast tissue to prevent or diagnose breast cancer. Why is it important to get a mammogram?- Early detection - women over 40 YO as a Pre-Disease Survey Test (see Screening >>)
- Woman with breast cancer risk factors -
- Women with breast cancer symptoms (see breast cancer symptoms >>)
How is the test done?
- The test is non-invasive and no preparation should be done in advance.
- Clothes and jewelery must be removed and the breast placed on the test surface of the machine.
- Sometimes there is a minor pain in the breast due to machine stress on breast surface
- The whole process took about fifteen minutes.
- Lymphatic SystemA system of tubes and glands that stores and carries white blood cells that fight infection. This system includes the bone marrow, the spleen, the thymus, the lymph nodes, and the lymphatic tubes similar to the blood vessels, which also reach all the tissues in the body.
- Immune SystemA complex system of cells (such as lymphocytes, neutrophils and monocytes) and organs (eg, spleen, bone marrow, thymus gland, etc.) aimed at fighting invasive organisms.
- Aromatase InhibitorsInhibit estrogen production in the body by inhibiting the aromatase enzyme responsible for producing estrogen. Aramex (generic name: Anastrozole, commercial name: Arimidex®), Aromasin (generic name: Exemestane), and Femara® (generic name: Letrozole, trade name: Femera®) are aromatase inhibitors approved for the treatment of breast cancer .
- Anti AngiogenesisTreatments that inhibit the formation of new blood vessels. Tumors survive and thrive in the body by causing the body to create around thhttps://trial-in.com/wp-admin/edit.php?post_type=glossaryem a vascular system that nourishes them and supplies them with oxygen.
- MalignantCancerous (not begnin)
- MelanomaA type of cancer that begins with melanocytes (cells that produce the pigment melanin). Cancer can begin in the skin but also begin in other pigmented tissues, such as the eye or intestines. It tends to spread to adjacent tissues, and can metastasize in the brain, lungs, bones, liver, and stomach.
- MicrometastasisA small number of cancer cells that have spread from the primary tumor to other parts of the body and are too small to be detected in a screening or diagnostic test.
- Bone ScanAn imaging test in which a radioactive marker (Tracer) is injected into the vein to diagnose various types of bone disease or bone tumor presence. The marking material is absorbed especially in areas where there is a great deal of bone dissociation or bone building. The radiation emitted from the radioactive material is absorbed by the camera that the technician transfers over the body. The amount of radiation accumulated in the skeletal bones is reflected in the picture.
- lymph node mappingSince tumor cells can spread through the lymphatic system, it is necessary to check whether the sentinel lymph node (the first lymph node in the lymphatic system to which the tumor drains) is infected with cancer cells. The sentinel lymph node is identified by injecting a radioactive substance or a dye solution (or both) into the tumor and then testing which lymph node is the first to contain the dye or the radioactive substance. The gland is removed and tested for the presence of cancer cells. If the gland is clean from cancer cellss, it is assumed that the rest of the lymph nodes are clean and need not be removed.
- Food and Drug Administration, FDAA US federal agency that aims to protect public health by ensuring that food, cosmetics and nutritional supplements are safe to use and honestly labeled.The FDA also ensures that medicines, medical devices, and equipment are safe and effective, as well as clinical studies after examining all aspects Relating to human health and was convinced that research could promote the proposed medicine for patients
- MyelomeCancer originating from plasma cells in the blood. Plasma cells are young cells before they differentiate into B cells that produce antibodies.
- Myalgiamuscle pain
- Retrospective StudyA retrospective study looks to the history and raises research questions about a group of subjects who have already participated in a treatment/trial/disease in the past. For example, checking the presence of mutation in the נןbiopsy of people who have participated in a clinical trial in the past. Biopsy samples are already in the hospital and there is no need to take new blood. The research is carried out on existing samples but asks new research questions
- Immune Check Points inhibitorsAlso called "immunotherapy" of drugs that help the immune system attack the tumor. This contrasts, for example, with chemotherapy that directly affects tumor cells. Examples of immunotherapy drugs are Keytruda® and Opdivo®
- Immunosuppressive barrierImmune barriers are the regulators of the immune system. These pathways are essential for tolerance processes and prevent autoimmune diseases, ie, those pathways that prevent the immune system from acting against the body itself. In cancer, these pathways are activated and as a result, the immune system does not attack the cancer. This way of cancer thrive in the body PD-L1 and CTLA-4 are types of training barriers. This therapeutic strategy has revolutionized the treatment of cancer in recent years and is one of the most studied strategies in the world for many types of cancer and different stages of treatment.
- Blood-brain barrier (BBB)Membrane which envelopes the brain and prevents penetration or entry of various chemicals into the brain, and that also includes drugs. Its purpose is not to allow harmful substances to reach the brain. Chemotherapy for brain tumors goes through this barrier.
- Advanced DiseaseThe disease worsens. For example, when the tumor grows in size and / or new metastasis has been created that did not appear before.
- Stable DiseaseA disease that remains stable, for example when the tumor is not getting smaller or larger.
- Bone MarrowA tissue usually found in the bones where blood cells are generated
- MesotheliomaCancer in the thin membrane surrounding the chest and the abdominal cavity.
- MorphinPain reliever for moderate to severe pain.
- MorbidityRefers to a disease or symptom of the disease, or the amount of disease within a population. Morbidity also refers to medical problems caused by treatment
- MutationA change to the DNA sequence in the cell. Mutations can be caused by errors during cell division, or they can be caused by exposure to substances harmful to DNA (free radicals, asbestos, etc.). Mutations can be harmful, beneficial, or have no effect. When they appear in egg or sperm cells, they can be inherited. If mutations occur in other types of cells, they are not inherited and are called somatic mutations. Mutations can lead to cancer or other diseases.
- MUC1A marker which is a protein called MUC1, which is normally present in mucous membranes and protects the body from foreign factors. A high blood level of the CA125 marker may indicate ovarian cancer, breast cancer, or other cancers
- MediastinoscopyA surgical procedure in which organs and tissues are examined in the mediastinum. Mediastenum is the area between the two lungs that contains the heart, large blood vessels, trachea, esophagus, and lymph nodes. This procedure is usually done to get a tissue sample from the lymph nodes on the right side of the chest.
- Statistically significantStatistical significance is the probability that relations between two or more variables is not random.
- Therapeutic IndexRisk vs. benefit of treatment. Used as a safety measure for treatments.
- LaparoscopeA thin pipe-like device with light and a lens. The laparoscope can be used as a tissue removal tool for further examination under a microscope.
- LaparoscopyA laparoscopy is a minimally invasive surgery uses an instrument called a laparoscope
- LumpectomyPartial breast removal according to tumor size. Removal can be up to 50% of breast size
- liposarcomaA sarcoma type of cancer from fat tissue.
- LymphocyteA white blood cell (leukocyte) produced in the bone marrow and found in blood and lymph tissue. There are two main types of lymphocytes: B and T lymphocytes. B lymphocytes produce antibodies, T lymphocytes help in killing tumor cells. T lymphocytes can activate B lymphocytes to start producing antibodies against a specific target.
- Non-Hodgkin LymphomaCancer that begins in the immune system cells. There are two basic subtypes of lymphomas: Hodgkin lymphoma, which is indicated by the presence of a cell type called Reed-Sternberg and non-Hodgkin lymphomas, which includes a large and diverse group of cancers of immune system cells. Non-Hodgkin lymphoma can be further divided into a cancer that has a slow (growing) course and those who have an aggressive course
- LymphomaCancer that begins in the immune system cells. There are two basic subtypes of lymphomas: Hodgkin lymphoma, which is indicated by the presence of a cell type called Reed-Sternberg and non-Hodgkin lymphomas, which includes a large and diverse group of cancers of immune system cells. Non-Hodgkin lymphoma can be further divided into a cancer that has a slow (growing) course and those who have an aggressive course
- lymphadenectomyA surgical procedure in which the lymph nodes are removed to prevent the spread of the tumor. Surgery can be regional or radical. In regional dissection, some glands are removed, usually those who are close to the tumor. In a radical dissection, all or most or all the lymph nodes in the tumor area are removed.
- lymphedemaDamage to the lymphatic system, such as lymph node removal, can cause the accumulation of lymph fluid in the organs. Edema in the legs and arms are common but can also be found in other parts of the body
- leukemiaLeukemia is a cancer of the blood tissue, including bone marrow and the lymphatic system. There are many types of leukemia, some of which are more common in children and some in adults. Leukemia usually results from the white blood cells
- LeukocyteWhite blood cells that produced in the bone marrow and are found in the blood and lymphatic tissues and are part of the immune system. Leukocytes are granulocytes (neutrophils, eosinophils and basophils), monocytes and lymphocytes (T cells and B cells). Blood leukocyte count is usually performed from a complete blood test and its level is used as an indicator of infection, inflammation, allergies, leukemia, and more
- leukopeniaLow number of blood cells.
- LobectomySurgery to remove a complete lobe from the penis. For example, lobe from the liver, lungs, brain.
- Compassionate useA way to provide medical care to a patient who is not eligible for treatment by participating in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. This extended approach allows the patient to receive promising anti-cancer treatments that have not yet been approved, when no other treatment is possible. Compassionate use, Early Access program, Named patient program
- Estrogen Replacement Therapy, ERTtment with estrogen hormone to increase the amount of estrogen in the body. This treatment is given to women who have passed menopause or to women who have menopausal symptoms preceded by anti-cancer treatments or surgery to remove the ovaries. Estrogen replacement therapy may relieve symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and sleep problems. The treatment should also help protect against osteoporosis and reduce the risk of breast cancer in postmenopausal women
- hormone replacement therapy, HRTTreatment with hormones to replace the natural hormones when the body does not produce them enough. For example, hormone replacement therapy may be given when the thyroid gland does not produce enough thyroid hormone or when the pituitary gland does not produce enough growth hormone. Alternatively, it may be given to postmenopausal women who do not produce estrogen and progesterone.
- Hormonal Therapy, Hormone TreatmentA treatment that increases or decreases the level of certain hormones in a body whose level of imbalance can cause cancer (such as prostate cancer and breast cancer). To slow or stop the growth of cancer, you can give synthetic hormones or other drugs to block the body's natural hormones. Surgery is sometimes needed to remove a gland that produces a certain hormone..
- Intracavitary Radiation TherapyA type of radiotherapy in which radiation source is placed in or near the area requiring treatment. Brachytherapy is commonly used to treat cancer of the cervix, prostate, breast, tongue and skin, and can also be used to treat tumors in other parts of the body
- Endocrine TherapyHormonal Therapy
- TomogrophyA imaging procedure in which a computer is connected to an x-ray machine and creates a series of detailed pictures of different areas of the body. Each tissue in the body absorbs radiation and returns radiation differently. The pictures are taken from different angles and are then processed to create a three-dimensional picture. Sometimes a contrast substance is injected into a vein or can be swallowed. The contrast material causes the tissues and organs to appear more clearly. CT can be used to help diagnose diseases, plan treatment, or find out how treatment works. The test is also called CT scan, CAT scan.
- Prophylactic OophorectomyOvarianctomy to prevent ovarian cancer and breast cancer
- Prophylactic MastectomyProphylactic surgery do decrease the risk of developing breast cancer which one or both breasts are removed before the disease develops. According to the National Cancer Institute, NCI, prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation may reduce the risk of developing breast cancer by 95%.
- Radical HysterectomySurgery to remove the uterus, cervix and part of the vagina. Ovaries, tubular tubes. The lymph nodes near the uterus may be removed.
- MetastasectomyMetastasis removal surgery
- Radical lymph node dissectionA surgical procedure to remove most or all of the lymph nodes from the area around the tumor. The lymph nodes are then examined under a microscope to see if cancer cells have spread to them. Radical lymph node dissection
- Lymph Node DissectionA surgical procedure in which the lymph nodes are removed to prevent the spread of the tumor. Surgery can be regional or radical. In regional dissection, some glands are removed, usually those who are close to the tumor. In a radical dissection, all or most or all the lymph nodes in the tumor area are removed.
- Radical cystectomySurgery to remove all the bladder and tissues and organs nearby.
- ChemoradiotherapyTreatment combining chemotherapy and radiotherapy.
- Microsatellite Stable, MSSWhen the tumor does not show the accumulation of mutations in the DNA "lien" regions (DNA regions with repetitive sequences).
- Genetic CounselorDiagnoses and advises on genetic diseases.
- Triple NegativeSub-population of the total population of breast cancer patients. The cancerous growth in the patients belonging to this population does not reflect the receptors of HER2, estrogen, and progesterone. Breast cancers are currently being cataloged according to the presence of these receptors.
- TeratogenMaterial, disease or environmental factor that has an adverse effect on the development of the fetus in the womb. Familiar teratogenes include Thalidomide drug, Rubella virus, or cytomegalovirus CMV, or X-rays.
- ThrombocytopeniaA low number of platelets in the blood because the body produces antibodies against them. Platelets form a blood clot when there is damage to the blood vessels and therefore this condition can lead to constant bleeding.
- PlateletsPlatelets are cells in the blood that accumulate in an area where blood vessels are damaged to stop bleeding.
- Tyrosine KinaseA group of protein molecules that are important, among other things, for cell division, metabolism and cell death. These molecules play an important role in the development of cancer and therefore pharma companies develop molecules to inhibit them. For Example: Lenvatinib is a multikinase, Tyrosine Kinase, inhibitor which has shown mainly antiangiogenic properties in vitro and in vivo, and direct inhibition of tumour growth was also observed in in vitro models.
- Combination therapyA treatment containing several drugs that work in different mechanisms.
- Palliative care treatmentPalliative care is a medical treatment whose purpose is usually to alleviate the patient's suffering in cases where the disease can not be cured. Awareness of such treatments is increasing.
- Systemic TreatmentTreatment that comes to all systems and organs in the body. Chemotherapy is systemic therapy. It affects normal dividing cells, not just cancer cells, and hence the many side effects associated with this type of treatment.
- Standard Of CareTreatment is accepted by experts for a particular type of disease.
- Maintenance TherapyTreatment that prevents cancer may recur and may be given for a long time.
- OutpatientTreatment without hospitalization.
- Local TreatmentTreatment of a specific organ or treatment limited to a specific area of the body. Local cancer treatment is surgery, radiotherapy, cryotherapy and laser therapy.
- Precision Medicine, Personalized MedicineIn cancer, personalized medicine uses the patient's specific disease characteristics and medical background to form a personalized therapy program
- Estrogen Replacement Therapy, ERTTreatment with estrogen hormone to increase the amount of estrogen in the body. This treatment is given to women who have passed menopause or to women who have menopausal symptoms preceded by anti-cancer treatments or surgery to remove the ovaries. Estrogen replacement therapy may relieve symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and sleep problems. The treatment should also help protect against osteoporosis and reduce the risk of breast cancer in postmenopausal women.
- Hormone replacement therapy, HRTTreatment with hormones to replace the natural hormones when the body does not produce them enough. For example, hormone replacement therapy may be given when the thyroid gland does not produce enough thyroid hormone or when the pituitary gland does not produce enough growth hormone. Alternatively, it may be given to postmenopausal women who do not produce estrogen and progesterone.
- Hormonal Therapy, Hormone TreatmentA treatment that increases or decreases the level of certain hormones in a body whose level of imbalance can cause cancer (such as prostate cancer and breast cancer). To slow or stop the growth of cancer, you can give synthetic hormones or other drugs to block the body's natural hormones. Surgery is sometimes needed to remove a gland that produces a certain hormone.. טיפול המוסיף או מוריד רמת הורמונים מסוימים בגוף שחוסר איזון ברמתם עלול לגרום לסרטן (כגון סרטן ערמונית וסרטן השד) . כדי להאט או לעצור את הצמיחה של סרטן, ניתן לתת הורמונים סינטטיים או תרופות אחרות במטרה לחסום את ההורמונים הטבעיים של הגוף. לפעמים נדרש ניתוח כדי להסיר בלוטה שמייצרת הורמון מסוים. Hormonal Therapy, Hormone Treatment טיפול הורמונלי
- Intracavitary Radiation TherapyA type of radiotherapy in which radiation source is placed in or near the area requiring treatment. Brachytherapy is commonly used to treat cancer of the cervix cancer, prostate cancer, breast cancer, tongue cancer and skin cancer, and can also be used to treat tumors in other parts of the body.
- Anti Androgen TreatmentThe aim of the treatment is to reduce the levels of male hormones, called androgens, in the body, or to prevent them from affecting cancer cells such as prostate cancer that stimulate prostate cancer cells to grow
- Endocrine TherapySee Hormonal Therapy value.
- TomogrophyA imaging procedure in which a computer is connected to an x-ray machine and creates a series of detailed pictures of different areas of the body. Each tissue in the body absorbs radiation and returns radiation differently. The pictures are taken from different angles and are then processed to create a three-dimensional picture. Sometimes a contrast substance is injected into a vein or can be swallowed. The contrast material causes the tissues and organs to appear more clearly. CT can be used to help diagnose diseases, plan treatment, or find out how treatment works. The test is also called CT scan, CAT scan.
- Case reportA case study is an advertisement in the medical press, which deals with a single case of the same researchers in depth. The scientific literature is full of case studies, as opposed to clinical cases, for example, which investigate large groups from which statistical data can also be obtained.
- Median SurvivalIn the statistics the median is the value out of the group, with an equal number of values preceded and followed. Median survival is the amount of time from the date of diagnosis or from the onset of treatment, such as cancer, that half of the patients in a group of patients diagnosed with the disease are still alive. In a clinical trial, measuring median survival is one way to see how well the new treatment works.
- False PositiveA result measured and determined as true but in fact the result is wrong, it is not real.
- True positiveA true result that has been verified
- Micro Satellite Instability, MSIMutations that accumulate in the DNA, in areas called "satellites" (repeating DNA sequences), as a result of errors occurring during DNA repair processes in a cell. Genetic instability can turn a normal cell into a cancerous cell.
- Folate, Folic AcidFolic acid is part of the vitamin B complex that the body needs for small amounts of healthy functioning. Folic acid helps produce red blood cells and is found in milk, whole grains, liver, green vegetables, orange juice, lentils, beans, and yeast. Folic acid is soluble in water and should be consumed every day. Lack of folic acid can cause anemia, cardiovascular disease, and brain and spinal cord defects in the fetus. Today, researchers are investigating the efficacy of folic acid with vitamin B12 in the prevention and treatment of cancer.
- InfectionThe invasion and growth of a foreign organism into the body. The organism can be a bacterium, fungus, virus or other. When the immune system functions normally, the body recognizes and responds to the foreign entity in order to prevent its spread. . Anti-cancer treatments can weaken the immune system and the body's ability to fight infection.
- EsophagusA muscular tube belonging to the digestive system that connects the pharynx (the lower part of the throat) to the stomach.
- TransformationA process in which normal cells become cancerous
- RemissionComplete reduction or disappearance of cancer symptoms. In partial remission some of the symptoms disappear as opposed to a complete remission in which all symptoms disappear, although the cancerous tumor may still be present in the body.
- InductionInduction is the first treatment given to a patient. This is often a standard part of a series of treatments, such as surgery followed by chemotherapy and radiation therapy.
- HematopoiesisThe process in whoch blood cells are formed
- AnestheticA procedure designed to suppress the nervous system in order to allow treatment without causing pain while maintaining proper body function. A general practitioner may perform local anesthesia, while the general anesthesia is performed by an expert anesthesiologist.
- HeparinA substance that slows the formation of blood clots. Heparin is produced for example by the liver and lungs. Synthetic heparin (which is produced not in the body but rather in the laboratory) can be injected into the muscle or blood to prevent or break blood clots. It is a type of anticoagulant.
- HemoglobinA protein found in red blood cells that binds oxygen when they move from the lungs to the rest of the body. When red blood cells move from tissues back to the lungs, hemoglobin binds carbon dioxide.
- Progression Free SurvivalThe length of time during and after the treatment in which the patient lives with the disease and its condition does not worsen.
- Overall Survival (OS)The time from the date of diagnosis or from the onset of the disease, such as cancer, that patients diagnosed with the disease are still alive. In a clinical trial, overall survival is measured in order to assess how well a new treatment works.
- Median SurvivalIn the statistics the median is the value out of the group, with an equal number of values preceded and followed. Median survival is the amount of time from the date of diagnosis or from the onset of treatment, such as cancer, that half of the patients in a group of patients diagnosed with the disease are still alive. In a clinical trial, measuring median survival is one way to see how well the new treatment works
- Recurrent Cancer, RelapseA cancer that usually comes back after a period of time when it could not be identified. Cancer may return to the same place as the original (primary) tumor or elsewhere in the body.
- HyperplasiaIncrease in the number of normal cells in the tissue. These cells look normal under the microscope. They are not cancerous but may become one.
- HypernephromaThe most common type of kidney cancer. The cancer starts with the renal tubule that filters the blood to produce urine.
- Radical HysterectomySurgery to remove the uterus, cervix and part of the vagina. Ovaries, tubular tubes. The lymph nodes near the uterus may be removed.
- HysterectomyHysterectomy is an operation to remove a woman's uterus
- HysterectomyHysterectomy is an operation to remove a woman's uterus
- Hyperalimentation,Total Parenteral Nutrition, TPNIntravenous feeding given to people who are unable to consume food through the digestive system due to vomiting, diarrhea or intestinal diseases. It can also be given to patients receiving high-dose chemotherapy and radiation therapy.
- Tube Enteral FeedingInserting a tube into the digestive tract for feeding purposes.
- Growth HormoneA protein produced and secreted by the pituitary gland that is responsible for controlling body growth and glucose and gat metabolism.
- HormoneMolecules (usually small proteins) that are secreted from glands in the body and regulate various processes in the body. Increased hormone production (eg, growth hormones) can cause cancer.
- Hodgkin lymphomaCancer that begins in the immune system cells. There are two basic subtypes of lymphomas: Hodgkin lymphoma, which is indicated by the presence of a cell type called Reed-Sternberg and non-Hodgkin lymphomas, which includes a large and diverse group of cancers of immune system cells. Non-Hodgkin lymphoma can be further divided into a cancer that has a slow (growing) course and those who have an aggressive course.
- DNAThe DNA is made up of two chains that form a double helix. The DNA contains genetic information. During cell division, the DNA replicated and each new daughter cell receives one copy of each DNA strand.
- Lumbar Puncture, Spinal TapA procedure in which a thin needle called a needle is inserted into the lower part of the spine to collect spinal fluid or give medication
- Radical Neck DissectionA rare medical procedure during which the lymph nodes are cut in the head and neck area, as well as adjacent tissues and organs such as muscles, veins, nerves and more. A procedure in which a thin needle called a needle in the spinal column is inserted into the lower part of the spine to collect spinal fluid or give medication.
- Neck DissectionSurgery to remove metastatic lymph nodes from the head and neck area to prevent tumor expansion by an ENT specialist in head and neck surgery.
- Lymphatic DissectionA surgical procedure in which the lymph nodes are removed to prevent the spread of the tumor. Surgery can be regional or radical. In regional dissection, some glands are removed, usually those who are close to the tumor. In a radical dissection, all or most or all the lymph nodes in the tumor area are removed.
- Axillary dissectionExcision of the axillary glands. In breast cancer, tumor cells can spread into the the lymph nodes of the armpit, therefore, axillary dissection has until recently been considered an integral part of breast cancer surgery. Today, sentinel node biopsy can estimate whether axillary dissection is necessary.
- DysplasiaWhen cells look abnormal under a microscope but are not cancerous.
- ImagingUsing imaging tools to take pictures of organs and tissues for diagnosis. Common imaging devices are MRI, CT and ultrasound.
- InflammationRedness, swelling, pain and / or feeling of heat in a particular area of the body. This is a protection reaction in cases of injury, disease or irritation of the tissues.
- Ductal Carcinoma In-Situ, DCISThe most common type of breast cancer. Ductal carcinoma tumor starts in the cells that line the milk ducts (a duct that transfers milk from the lobules to the nipple). Dectal carcinoma can be localized (without metastases) and then called inactivated carcinoma (DCIS).
- Ductal CarcinomaThe most common type of breast cancer. Ductal carcinoma tumor starts in the cells that line the milk ducts (a duct tha transfers milk from the lobules to the nipple). Dectal carcinoma can be localized (without metastases) and then called inactivated carcinoma (DCIS). When the cancer cells have spread outside the breast milk ducts, the cancer is called invasive ductal carcinoma.
- athology ReportA report written by a pathologist with findings from a biopsy diagnosis under a microscope.
- DebukingTumour removal by surgery in order to increase the efficacy of another treatment such as chemotherapy and radiation.
- MicrometastasisA small number of cancer cells that have spread from the primary tumor to other parts of the body and are too small to be seen in a screening or diagnostic test.
- osteolytic metastasesBone metastasis
- MetastasisA cancerous growth in organs far from the primary tumor. Metastatic cells have the same characteristics as the original cancer cells, even if they are found in another organ. For example, tumor cells found in the lung can originate from a primary tumor located in the colon rather than a lung cancer
- GastrectomyStomach removal. The removal can be complete or partial
- GastroscopyExamination of the upper gastrointestinal tract (esophagus, stomach and duodenum). During the examm, a small camera located at the tip of a flexible tube, is inserted through the mouth called a gastroscope
- GastroenterologyA branch of medicine that deals with the digestive system and diseases related to the digestive system.
- GenericOfficial nonbrand names of drugs
- GenomeThe full system of all the genes in an organism. In humans, all genes are located on structures called chromosomes. Chromosomes are complexes of DNA and proteins bind to each other. Almost every cell in the body contains a complete copy of the genome. The genome contains all the information a person needs for development and growth. The Genome study provides an understanding of how cancer cells are formed and respond to therapy. People with different genetic will respond differently to a particular drug. For example, So certain drugs that are not given to people with certain DNA mutations.
- Tumor Suppressor Gene
Genes that slow cell division participate in the process of correcting DNA errors, or that signal the cell do dies. When tumor suppressor genes fail to function properly, cells can get out of control and become cancerous.
- GeneA fragment in the DNA strand that encodes physiological features, for example, eye color. The genes genes are inherited upon cell division when the DNA molecule replicates, and each new cell receives a copy of the replicated DNA.
- GliomaA type of a brain cancer that develops from glial cells that support neurons (cells of the nervous system).
- Gastro-intestinal Stromal Tumor, GISTA type of tumor that usually originates from cells in the wall of the digestive system. The tumor can be benign or malignant.
- Granulocyte-colony stimulating factor , G-CSF, GCSFGCSF Promotes the formation of white blood cells in the bone marrow. Chemotherapy drugs can cause neutropenia, which can cause infections. The drug Pilgrims (synthetic GCSF manufactured in the laboratory) is given in this condition. Generic Name: Filgrastim Trade Name: Neupogen®, Granix®, Zarxio
- Second primary cancerWhen an tumor appears after the patient has had a tumor in the past. Chemotherapy and radiation therapy can cause the second tumor.
- TumorA cluster of cells that grow abnormally. Not every tumor is malignant. Tumor can be benign. In time a benign tumor can transform into a malignant tissue.
- BrachytherapyA type of radiotherapy in which radiation source is placed in or near the area requiring treatment. Brachytherapy is commonly used to treat cancer of the cervix cancer, prostate cancer, breast cancer, tongue cancer and skin cancer, and can also be used to treat tumors in other parts of the body.
- LymphedemaDamage to the lymphatic system, such as lymph node removal, can cause the accumulation of lymph fluid in the organs. Edema in the legs and arms are common but can also be found in other parts of the body.
- EdemaSwelling due to excess fluids in the tissue.
- Node-NegativeLymph node not infected with cancer cells
- Node-PositiveLymp node infected with cancer cells
- Lymph NodeLymph nodes are part of the lymphatic system which is made up of glands and tubes. Fluid from tissues in the body reaches the lymph nodes that filter and clean it. The lymph nodes also contain lymphocytes (mostly B cells and T cells) that reach the body's various tissues when needed, for example, local tissue inflammation. Lymph nodes are located in the neck, armpit, chest, abdomen, and groin. Cancer can spread through the lymphatic system
- Lymph NodeLymph nodes are part of the lymphatic system which is made up of glands and tubes. Fluid from tissues in the body reaches the lymph nodes that filter and clean it. The lymph nodes also contain lymphocytes (mostly B cells and T cells) that reach the body's various tissues when needed, for example, local tissue inflammation. Lymph nodes are located in the neck, armpit, chest, abdomen, and groin. Cancer can spread through the lymphatic system.
- AxillaAn area under the shoulder through which blood vessels and nerves enter and go out to the arm. A lump in the armpit can indicate an enlarged lymph node.
- OverexpressionA condition in which the cell produces more proteins than normal. For example, breast cancer cells or stomach cancer cells produce the HER2 protein in access.
- BiosimilarA biological drug that acts as an original biological drug. The term “biosimilar”replaces the term "generic" used in traditional drugs.
- Fine Needle AspirationA process I which a fine needle is used to drain a fluid from the tumor. Usually performed under anesthesia.
- Bone Marrow BiopsyBone marrow is a spongy tissue within the bones where red blood cells, platelets, cartilage, fat cells and bone cells are produced. Bone marrow biopsy is performed under local anesthesia, using a needle that is usually inserted into the femur. The biopsy is sent to the laboratory to check for abnormal cells. The abnormal formation of cells can happen during inflammation, infection or cancer.
- Frozen Section BiopsyRapid test for cancer cells detection. The biopsy is removed from the patients’ body by the surgeon who is then giving it to a pathologist who then freezes the biopsy and slices it into thin slices and examines the slices under the microscope.
- Sentinel Lymph Node BiopsySince tumor cells can spread through the lymphatic system, it is necessary to check whether the sentinel lymph node (the first lymph node in the lymphatic system to which the tumor drains) is infected with cancer cells. The sentinel lymph node is identified by injecting a radioactive substance or a dye solution (or both) into the tumor and then testing which lymph node is the first to contain the dye or the radioactive substance. The gland is removed and tested for the presence of cancer cells. If the gland is clean from cancer cellss, it is assumed that the rest of the lymph nodes are clean and need not be removed.
- BiopsyRemoval of tissue from the body for pathological diagnosis in the laboratory.
- BiomarkerA molecule in the blood, other body fluids, or tissue that is a marker for a normal or abnormal process, such as a disease. Biomarker may be used to see how much the body responds to a certain treatment. For example, HER2 , when overexpressed, is a biomarker for cancer cells.
- BolusRapid administration of a drug into the body.
- Progesterion Receptor TestA laboratory test to determine if the cancer cells have progesterone receptors (proteins in the cell to which progesterone is attached). If the cells have progesterone receptors, they may need this hormone to grow, which may affect how cancer is treated.
- Estrogen Receptor TestA laboratory test to see if cancer cells have estrogen receptors (proteins in the cell to which estrogen binds). If the cells have estrogen receptors, they may need estrogen to grow, which may affect how cancer is treated.
- Fecal Occult Blood Test, FOBTA hidden blood test in the stool. Blood in the stool may be a sign of colon cancer or other problems, such as polyps, ulcers or hemorrhoids.
- Genetic TestingThe process of analyzing the DNA of cells or tissues to look for genetic changes that may be a sign of a disease such as cancer.
- Senital Node Test
- Senital NodeThe first lymph node in the lymphatic system to which the tumor drains. Tumor cells can spread through the lymphatic system
- ErythrocytePhysical examination of the vagina, cervix, uterus, tubular tubes, ovaries and anus. Vagina examination is performed by inserting a speculum device to expand the vagina and cervix. The collected samples can be used for a Pap test, or for testing sexually transmitted diseases or other infections. During the examination, the doctor inserts two fingers into the vagina, presses the lower abdomen with the other hand to feel the presence of lumps and check the size, shape and location of the uterus and ovaries.
- erythropoietinHormone produced and secreted by the kidneys that stimulates the bone marrow to produce red blood cells. For example, Epoetin alfa (Generic name: Epoetin alpha, trade name: BINOCRIT®) and Epoetin beta (Generic name: Epoetin beta, trade name: RECORMON®) are the synthetic version (produced in the laboratory) of the natural hormone.
- AromataseAn enzyme that participates in the synthesis of estrogen. Aromatase is found in many tissues such as brain, placenta, fat tissue, and more.
- ERBB2, HER2, HER-2A protein involved in cellular processes such as angiogenesis , differentiation, growth, and more. HER2 can be found in high levels in breast, ovarian, bladder, pancreas and stomach cancers and cause cancer cells grow faster and spread. At the present, a number of biological drugs exist that bind to this protein and prevent its proliferation.
- Pelvic ExenterationSurgery to remove the lower colon, anus, and bladder. The goal of the surgery is to create openings through which the urine and excrement will come out of the body. In women, the cervix, vagina, ovaries, adjoining lymph nodes are also removed.
- AcuteDevelops quickly.
- Epithelium (epithelial cells)Tissues in the human body are integrated from different types of cells. Epithelial cells, that that cover the surfaces of the body that come into contact with the exterior world. These cells are found, for example, in the skin, mouth and nose.
- EpidemiologyA branch of medicine which deals with the distribution and control of diseases.
- Estrogen Receptor Negative, ER+When cells in the patient express a low level of estrogen, suggesting that the cause of tumour growth is not dependent on the hormone estrogen.
- Estrogen Receptor Positive, ER+Estrogen receptor positive cells express high levels of estrogen receptors. In such a situation, the treatment may consist, among other things, of aromatase inhibitors that inhibit estrogen production.
- EstrogenHormones produced in the woman body that help develop and maintain the characteristics of female sex and the growth of long bones. Esteriol, for example, is a type of estrogen. Estrogens bind to the estrogen receptor (Estrogen Receptor, ER). Estrogen in some cases can be involved in development of breast cancer - 80% of breast cancer patients are ER positive, meaning that their tumor responds positively estrogen molecules in the body. These patients will be treated with estrogen blockers, which block the estrogen receptor
- EnteralThrough the digestive system. The delivery of an anteral drug is given through the digestive system. Methods of administration include oral, sublingual (dissolving the drug under the tongue), and rectal.
- Anaplasia (Anaplastic)A condition in which cells lose their morphological characteristics of mature cells.
- AnemiaDecreased red blood cells (erythrocytes) or hemoglobin (a protein in the red blood cells responsible for oxygen binding). The cancerous mour and / or anti-cancer treatment can cause anemia.
- AnalgesticPain killers
- AnticoagulantSubstances that inhibit the process of blood clotting
- AntioxidantOxidation is a chemical reaction that produces free radicals that may damage cells in the human body. Antioxidants are molecules that inhibit the formation of free radicals that can transform normal cells into cancer cells.
- Carcinoembryonic AntigenCarcinoembryonic antigen ( (CEA) is glycoprotein (a protein with sugar groups attached to it) that is usually found in very low levels in blood of healthy adults. CEA blood levels can be increased in Venous thrombosis is common in cancer patients. pain killer. choice in monitoring the effectiveness id anti cancer treatments. High blood concentrations of the CA-125 marker can indicate ovarian cancer and the high blood level of the CA-724 marker may indicate gastrointestinal adenocarcinomas
- AntigenAny substance that causes the body to produce an immune response against this substance. Antigens include toxins, chemicals, bacteria, viruses or other substances that come from outside the body. There are antigens on the tissues of the body and cells, including cancer cells, which when expressed abnormally, they cause an immune response. These antigens can also be used as biomarkers in laboratory tests to identify cancerous cells.
- AntiOpposed to, against.
- AndrogenHormones responsible for male sex characteristics eg testosterone. Androgen receptors (receptors) play an important role in the development of prostate cancer.
- EndoscopyA procedure that uses an endoscope to examine the the interior of a hollow organ or cavity of the body. An endoscope is a thin tube-like device with light and a viewable lens. An endoscope is also used to remove a biopsy for further examination under a microscope for signs of disease.
- AngiogenesisBlood vessels grow. In cancer, a blood vessel system forms around the tumor and supplies it an energy and oxygen
- EmesisVomiting
- ALK1Activin receptor like kinase 1, ALK1. A protein found on blood vessel cells. Crizotinib® (generic name: Crizotinib) is a ALK1 inhibitor that inhibits the formation of new blood vessels around the tumor.
- Ductal Carcinoma In-Situ, DCIS
- in-situLocal. When the tumour remains in the tissue from which it was originated and has not yet metastasized or migrated to other tissues.
- InfusionFluid delivery into the body through the vein
- IndolentIdolant cancer develops slowly.
- InterferonA protein, type of cytokinein group plays an important role in the immune system
- Interleukin (IL)A protein, type of cytokinein group plays an important role in the immune system
- ImmunotherapyImmunotherapy drugs assist the immune system in attacking the tumor. The immune system has “immune barriers” which serve to regulate the immune system and prevent it from attacking the body. In cancer these functions are readily activated and as a result, the immune system ceases to attack cancerous cells, enabling the tumor to grow and proliferate in the body. For example, the biological drug Opidivo, Nivolumab, and Keytruda®,Nivolumab.
- Quality of Life, QOLThe general enjoyment of life. Many clinical trials assess how cancer and cancer treatments impact life. These studies measure aspects of the individual's sense of well-being and his ability to perform daily life activities.
- IdiopathicFrom unknown source
- EsophagectomyPartiPartial removal of the esophagus depends on the disease stagesVal
- OsteosarcomaSarcoma is a type of a cancer that begeins in the bone. It usually appears in arms or legs.
- OncologyA branch of medicine that specializes with cancer diagnosis and treatment.
- OncologistA physician specializing in the diagnosis and treatment of cancer.
- OncogeneA gene that, when mutated, enhances the formation of a cancerous tumor or accelerates cancer growth.
- Transrectal endoscopic ultrasound, TRUSAn imaging procedure for the evaluating the size and penetration of tumors in the anus and rectum.
- UltrasoundAn imaging technique in which sound waves transmitted to the area of the body being tested at a frequency that the human ear can not hear. The wave returns to a device that processes it into a picture. This is a safe test unlike X-rays or CT, in which the subject is not exposed to ionizing radiation. The technique is used to diagnose cancer
- AdenocarcinomaMalignant tumor in the form of a gland created from epithelial cell tissue that release mucus, digestive juices, saliva, etc. Adenocarcinoma is common in breast cancer, pancreatic cancer, colon cancer, lung cancer, and prostate cancer.
- AdenomaA benign (non cancerous) epithelial growth with a structure of a gland.
- AdjuvantTreatment given to a patient to increase the therapeutic effect of a different treatment, such as surgery or radiotherapy. Typically, adjuvant is a chemotherapy treatmnet that is given after the first treatment in order to reduce the risk of cancer recurrence.
- LHRH AgonistA class of drugs that prevent the testes and ovaries from producing sex hormones. These drugs are given as a treatment for prostate cancer, for example, against tumors that developed in response to testosterone hormone. Among women, the drugs will block the production of estrogen and progesterone.
- Abnormalunusual, not normal
- AblationA medical in which tissue is removed by chemical substances (chemoablation), extreme cold (cryoablation), laser (photoablation) or radiofrequency ablation (RFA).