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What Is Chemotherapy?

Chemotherapy is a medications that damage the cells divide into the body.

Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body.

Chemotherapy’s impact has a range of side effects such as hair loss, loss of appetite, changes to bowel movements, fatigue, infection, hemorrhaging, incontinence, pain, and more.

Chemotherapy will be given with or without radiation

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Folfirinox is a combination of 4 anti cancer drugs:

  1. Leucovorin
  2. Adrucil®, (Fluorouracil, 5-FU)
  3. Camptosar®, Campto®, (Irinotecan)
  4. Eloxatin®, (Oxaliplatin)

Gemzar®, gemcitabine and one or two of this drugs:

Examples of standard chemotherapy protocols for treating breast cancer:

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation


  1. The existing therapies used on stage 4 metastatic cancer are not curative, and this is a source to the need for innovative and effective treatment strategies in order to fight the disease.
  2. The National Cancer Institute, NCI, highlights the fact that for a certain group of cancer patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success.
  3. Currently, every patient will be offered the standard protocols described above. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute.

The opportunity

  1. Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have already been recognized by the US Food & Drug Administration, the FDA, as “breakthrough drugs” and require further information to be approved.
  2. An entire world of clinical trials, Compassionate drugs and advanced new cancer treatments are available worldwide.
  3. It is important to know and have access to cutting edge cancer treatments that best match the unique medical condition of the patient and increase chances in winning the fight against compared to the standard care offered.

Read our publications on innovative treatments and chemotherapies:

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We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

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Breast Cancer – Benefits of Trodelvy in HR+/HER2-


The antibody-drug conjugate Trodelvy offers statistically and clinically significant benefits for patients with heavily pretreated HR+/HER2- breast cancer, according to results of the TROPiCS-02 study, recently presented.

HR+/HER2- is defined as hormone receptors positive – ER and PR positive – and HER2 status negative breast cancer.

Heavily pretreated patients are patients who have failed at least two prior chemotherapy regimens in this study.

Breast cancer is a leading cause of cancer death, and HR+/HER2- disease is the most common subset, representing approximately 70% of this disease. For metastatic, HR+ breast cancer, international guidelines recommend sequential endocrine therapy, starting with first-line endocrine drug, like Tamoxifen, Letrozole and others given in combination with CDK4/6 inhibitor drugs, like Verzenio, Ibrance and Kisqali.

When resistance to endocrine therapy develops, single-agent chemotherapy is recommended but is associated with declining efficacy and increased toxicity.

So, in later lines of treatment there are limited options to offer patients.

What is Trodelvy?

Trodelvy is directed to Trop-2. Trop-2 is a biological entity is overexpressed in many cancers, including breast cancer, and is associated with poor survival. About 80% of breast cancer tumors highly express Trop-2.

It is currently approved for use in metastatic Triple-Negative Breast Cancer patients who have received at least 2 prior therapies, with at least 1 given in the metastatic setting.

About the TROPiCS-02 Study in Breast Cancer

The goal of this phase III study was to determine whether Trodelvy can help fulfill the clinical need in HR+/HER2-, in which patients were randomized to receive Trodelvy or treatment of physician’s choice (Xeloda, Halaven, Navelbine, or Gemzar) until disease progression or unacceptable toxicity.

All patients had received 2 to 4 prior chemotherapy protocols.

Study Results

Trodelvy was associated with better median PFS (Progression Free Survival, which is the length of time until progression of the disease or unacceptable toxicity) vs physician’s choice: 5.5 versus 4.0 months.

The percentage of patients with no disease progression or unacceptable toxicity at 6-month was 46% versus 30% and at 12-month was 21% versus 7%, in favor of Trodelvy.

In the first of three planned OS analyses, the median Survival was 13.9 months with Trodelvy versus 12.3 months with physician’s choice therapy.

The percentage of patients who experienced decrease in the volume of their tumors was 21% versus 14% in favor of Trodelvy.

The percentage of patients who experienced decrease in the volume of their tumors plus stable disease (no change) was 34% versus 22% in favor of Trodelvy.

Overall, 74% in the Trodelvy arm versus 60% of patients in the physician’s choice arm experienced harsh side effects.

Unfortunately, there was 1 treatment-related death in the Trodelvy arm and none in the treatment of physician’s choice arm.

Key Messages for Breast Cancer patients

  • Trodelvy demonstrated PFS benefit over chemotherapy in
  • A higher proportion of patients were alive and progression-free
  • Trodelvy also demonstrated an overall health-related quality of life benefit over chemotherapy, with delayed deterioration in fatigue.


Trodelvy demonstrated significant and clinically meaningful benefit and should be considered a potential treatment option in this heavily pretreated population of HR+/HER2- breast cancer.

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Breast Cancer - Benefits of Trodelvy in HR+/HER2-
Breast Cancer – Benefits of Trodelvy in HR+/HER2-

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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

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