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Chemotherapy

What Is Chemotherapy?

Chemotherapy is a medications that damage the cells divide into the body.

Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body.

Chemotherapy’s impact has a range of side effects such as hair loss, loss of appetite, changes to bowel movements, fatigue, infection, hemorrhaging, incontinence, pain, and more.

Chemotherapy will be given with or without radiation

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Folfirinox is a combination of 4 anti cancer drugs:

  1. Leucovorin
  2. Adrucil®, (Fluorouracil, 5-FU)
  3. Camptosar®, Campto®, (Irinotecan)
  4. Eloxatin®, (Oxaliplatin)

Gemzar®, gemcitabine and one or two of this drugs:

Examples of standard chemotherapy protocols for treating breast cancer:

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation

Facts

  1. The existing therapies used on stage 4 metastatic cancer are not curative, and this is a source to the need for innovative and effective treatment strategies in order to fight the disease.
  2. The National Cancer Institute, NCI, highlights the fact that for a certain group of cancer patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success.
  3. Currently, every patient will be offered the standard protocols described above. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute.

The opportunity

  1. Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have already been recognized by the US Food & Drug Administration, the FDA, as “breakthrough drugs” and require further information to be approved.
  2. An entire world of clinical trials, Compassionate drugs and advanced new cancer treatments are available worldwide.
  3. It is important to know and have access to cutting edge cancer treatments that best match the unique medical condition of the patient and increase chances in winning the fight against compared to the standard care offered.

Read our publications on innovative treatments and chemotherapies:

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Improve therapeutic outcomes, prolong life and quality of life are our main business. We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

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Unheard of efficacy with combination of two approved drugs in the treatment of ovarian and endometrial cancers

In mid March 2019, the international annual meeting of the Society of Gynecologic Oncology, the SGO, was held.

At the meeting, experts from the field presented their work in the areas of endometrial cancer, cervical cancer and ovarian cancer.

One of the most powerful studies presented, was a pilot study using combination of chemotherapy and a targeted agent in platinum-resistant ovarian cancer and recurrent endometrial cancer. The two drugs are Lenvima, which a cancer drug belongs to a family of targeted drugs and the second drug is a common chemotherapy named Taxol.

Study description

In this phase I trial, patients with recurrent endometrial and patients with platinum-resistant epithelial ovarian cancer were treated with the combination of Lenvima®, a tyrosine kinase inhibitor, and a weekly dose of Taxol.

Results

Weekly Taxol has been used for these diseases for many years with a very modest and unsatisfactory response rate.

The addition of Lenvima® to Taxol has dramatically raised treatment efficacy to overall response rate of 65% – About two third of patients responded to the combination: Their disease either stopped from growing or shrunken.

Yet, there are adverse events to the combination treatment and they are common, that may become a limitation in a larger population.

The News

The response rate was 71% in patients in the ovarian cancer group and 50% in patients with endometrial cancer.

The primary objective of the trial was to identify the right and most suitable dose of the combination for a continuing Phase II clinical trial.

In addition, secondary endpoints included follow-up on safety and tolerability, antitumor activity, pharmacokinetics and duration of treatment until further progression of disease.

To Summarize

It is almost unheard of such results in this population. Even though it was a very small trial on 26 patients, the efficacy observed was impressive!

There is no doubt that participation in Phase I clinical trials can also be of great benefit to cancer patients and by the time Phase II and Phase III clinical trials will be launched, the same patients who had joined this study – had won!

 

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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

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