What Is Chemotherapy?

Chemotherapy is a medications that damage the cells divide into the body.

Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body.

Chemotherapy’s impact has a range of side effects such as hair loss, loss of appetite, changes to bowel movements, fatigue, infection, hemorrhaging, incontinence, pain, and more.

Chemotherapy will be given with or without radiation

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Folfirinox is a combination of 4 anti cancer drugs:

  1. Leucovorin
  2. Adrucil®, (Fluorouracil, 5-FU)
  3. Camptosar®, Campto®, (Irinotecan)
  4. Eloxatin®, (Oxaliplatin)

Gemzar®, gemcitabine and one or two of this drugs:

Examples of standard chemotherapy protocols for treating breast cancer:

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation


  1. The existing therapies used on stage 4 metastatic cancer are not curative, and this is a source to the need for innovative and effective treatment strategies in order to fight the disease.
  2. The National Cancer Institute, NCI, highlights the fact that for a certain group of cancer patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success.
  3. Currently, every patient will be offered the standard protocols described above. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute.

The opportunity

  1. Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have already been recognized by the US Food & Drug Administration, the FDA, as “breakthrough drugs” and require further information to be approved.
  2. An entire world of clinical trials, Compassionate drugs and advanced new cancer treatments are available worldwide.
  3. It is important to know and have access to cutting edge cancer treatments that best match the unique medical condition of the patient and increase chances in winning the fight against compared to the standard care offered.

Read our publications on innovative treatments and chemotherapies:

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Improve therapeutic outcomes, prolong life and quality of life, is our main business.
We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

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Gastric Cancer – Zolbetuximab Prolongs Survival

About Locally Advanced Unresectable Metastatic Gastric Cancer and Gastroesophageal Junction Cancer (GEJ)

Gastric cancer is the fifth most diagnosed cancer worldwide.

Signs and symptoms can include indigestion or heartburn; pain or discomfort in the abdomen; nausea and vomiting; diarrhea or constipation; bloating of the stomach after meals; and loss of appetite and sensation of food getting stuck in the throat while eating.

Signs of more advanced gastric cancer can include unexplained weight loss; weakness and fatigue; and vomiting blood or having blood in the stool.

Risk factors associated with gastric cancer can include older age, male gender, family history, H. pylori infection, smoking and gastroesophageal reflux disease (GERD).

Because early-stage gastric cancer symptoms frequently overlap with more common stomach-related conditions, the disease is often diagnosed in the advanced or metastatic stage, or once it has spread from the tumor’s origin to other body tissues or organs.

Gastric and GEJ cancers still have very limited treatment options available for patients with an advanced diagnosis.

About the Spotlight Study

Spotlight is a global, multicenter, double-blind, randomized study that is investigating the efficacy and safety of zolbetuximab.

Approximately 566 patients have been enrolled in the study.

In arm A, patients received combination with zolbetuximab and mFOLFOX6.

After mFOLFOX6 is complete, patients are permitted to receive fluorouracil (5-FU) and folinic acid until the patient meets the study treatment discontinuation criteria.

Patients in arm B are administered matching placebo and mFOLFOX6 and may also receive 5-FU and folinic acid after mFOLFOX6 completion.

The study is ongoing at 220 locations worldwide.

It is expected to be completed in January 2025.

In addition to Spotlight, zolbetuximab is also being investigated in combination with capecitabine and oxaliplatin (CAPOX) vs placebo and CAPOX in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric adenocarcinoma (GLOW; NCT03653507).

Spotlight Results in Gastric Cancer and Gastroesophageal Junction Cancer

Initial results from the phase 3 spotlight study show that the study met its primary and key secondary end point of the duration of the period patients did not progress (also called “Progression-Free Survival, PFS) and Survival.

Treatment with zolbetuximab plus chemotherapy led to statistically significant progression-free survival (PFS) improvement in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.

These topline results further support the role of CLDN18.2 as an emerging biomarker in gastric and GEJ cancer.

Talk to us so see if we can help you to actually get the most advanced treatments


Because we, do not give up on life!

Contact us 24/7 –

Call center +44.2082.426.039

Read more about Gastric cancer >>


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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

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