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Immunotherapy

What is Immunotherapy?

Immunotherapy is a treatment that activates or suppresses the immune system and by that assist the immune system in attacking the tumor. This type of treatment is very different from chemotherapy, for example, which directly attacks the cancerous cells but unfortunately also damages healthy tissues.

The immune system has “immune barriers” which serve to regulate the immune system and prevent it from attacking the body. In cancer these functions are readily activated and as a result, the immune system ceases to attack cancerous cells, enabling the tumor to grow and proliferate in the body.

Barriers known as PD-L1, PD-1 and CTLA-4 are found on T-cells and cancer cells. For example, the biological drug Opidivo® (generic name: Nivolumab) activates the immune system against the tumor.

Immunotherapy is a revolutionary strategy, and one of the most widely studied worldwide for its application to numerous types of cancer and various stages of the disease’s development. Treatment is generally provided in the form of an intravenous infusion.

Immunotherapy drugs examples:

PD-1 drugs:
• Keytruda® (Pembrolizumab)
• Opdivo® (Nivolumab)

PD-L1 drugs:
• Tecentriq® (Atezolizumab)
• Imfinzi® (Durvalumab)

What are the most common side effects?

Reaction of the skin

Redness, blisters and dryness. The skin can become sensitive when exposed to sunlight. Inflammation around the fingernails can occur and cause pain when dressing, for example.

Flu-like symptoms

Fatigue, fever, chills, nausea, vomiting, dizziness, body pain and high or low blood pressure

Other side effects may be:

  • Muscle Pain
  • Difficulties in breathing
  • Swelling of the legs
  • Sinus congestion
  • Headaches
  • Weight gain due to accumulation of fluids
  • Diarrhea
  • Hormonal changes
  • Cough

And there could be more

Most of the side effects will disappear at the end of the immunotherapy treatment, but some can occur months and even years later.

It is important to consult with your healthcare professional about coping with side effects.

TRIAL-IN-Pharma offers a unique, personalized research and analysis for patients with metastatic cancer and brain tumors, which reveals innovative and advanced oncologic treatments around the world and support the process of achieving them.

Read our publications on immunotherapy and other innovative treatments for stage 4 metastatic cancer:

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Encouraging News in Bladder Cancer Treatment 🎯

Posted on September 19, 2024

What’s This About? 🔍

A promising new study examined the combination of two drugs, Rogaratinib Plus Atezolizumab,

in patients with locally advanced or metastatic bladder cancer,

who cannot receive Cisplatin treatment (standard chemotherapy).

The study focused on patients whose tumors express high levels of a special protein called FGFR.

How Does It Work? 💊

Rogaratinib is a drug that blocks FGFR receptors involved in cancer growth,

and Atezolizumab is an immunotherapy drug that helps the immune system fight cancer cells.

The combination is designed to enhance treatment effectiveness.

What Did They Find? 📊

The results are particularly impressive! ✨

  • 53.8% of patients responded to the combination therapy
  • 15% of patients achieved complete response (tumor disappearance)!
  • The treatment was effective even in patients with low levels of PD-L1 marker (which typically predicts poor response to immunotherapy)
  • Side effects were manageable, with the most common being diarrhea (62%) and high phosphate levels in blood (51%)

Why Is This Important? 💫

This is especially significant news for patients who cannot receive standard chemotherapy treatment!

The new combination offers a promising treatment option that can help a broad group of patients.

Remember, we’re here for you ❤

Locating and supporting access to innovative drugs and advanced treatments for metastatic and stage 4 patients worldwide 🌍

Share this post – it might help someone you know! 🤝

Yours,
Nir Erez / Trial-In Pharma 👨‍⚕

To read the article >>
https://jamanetwork.com/journals/jamaoncology/fullarticle/2823971?guestAccessKey=71a62218-22e3-4276-8b09-60882d4e770e&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamaoncology&utm_content=etoc&utm_term=112224&utm_adv=000002654648

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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

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