Personalized Cancer Vaccines: The Complete Guide
Comprehensive overview of the revolution in immunotherapy: From Germany to the USA
There are several global biotech companies performing personalized vaccines, including Moderna (USA), BioNTech and CureVac (Germany), and PreciOnco. We at Trial-In Pharma work with the most advanced centers and match the right destination for the patient.
As an example of the process, we present here the protocol of the German company PreciOnco, which offers a unique track for identifying neo-antigens. We accompany patients who choose this track and other tracks worldwide.
Costs vary between countries and providers. In the case of PreciOnco, the cost is tiered: initial payment for analysis followed by payment for production. (Full details later on the page).
We are your bridge. We are not the "vaccine company" but the professional body that accompanies you, makes information accessible, and manages the medical and logistical connection with centers abroad.
Treatment Track Example: PreciOnco
PreciOnco from Germany is one of the pioneers in the field of genetic diagnosis and personalized immunotherapy.
How does it work? (PreciOnco Model)
Analysis & Planning Phase
At this stage, the performing company analyzes the tumor:
- 🧬 Genetic Sequencing: Comparison between a tumor sample and a blood sample.
- 🔍
Production & Vaccination Phase
After the analysis, the vaccine is produced:
- ⚗️ Peptide Production: Creating 15–20 unique peptides in the laboratory.
- 💉 Injection Series: Administering the vaccine combined with adjuvants at the medical center.
Tumor Tissue & Sample Requirements (PreciOnco Example)
To begin the analysis and vaccine production, samples meeting the following conditions must be provided:
| Sample Type | Technical Requirements |
|---|---|
| Tumor Block (FFPE) | At least 2 blocks. Minimum size 5x5x5 mm. Minimum tumor content 20%. |
| OR: Tissue Sections | Minimum 15 unstained tissue slices on glass slides. Thickness: 4-10 µm, Size: 5x5 mm. |
| H&E Staining | 1x corresponding H&E-stained slide, if available. |
| Blood Sample | 1x tube of 2-3 ml EDTA whole blood. Do not cool; keep at room temperature after collection. |
Annual Treatment Protocol
Treatment requires arrival at the medical center for injection dates only.
What's Included?
- ✅ Full deep genetic diagnosis
- ✅ Personalized peptide design & production
- ✅ 14 injections and treatments at the center
- ✅ Tumor Board multidisciplinary discussion
- ✅ Ongoing monitoring of immune response
Treatment Costs (PreciOnco Example)
Payment is tiered and transferred directly to the provider based on phase progress
Why go through the process with Trial-In Pharma?
The world of cancer vaccines is evolving rapidly with centers in Germany, the USA, and more. We provide you with the professional compass:
- ✅ Global Mapping: We know the various companies (PreciOnco, Moderna, etc.) and guide you to the right place.
- ✅ Medical & Scientific Support: Our oncologists and biologists analyze data to ensure you are in good hands.
- ✅ Logistical Bridge: Managing bureaucracy and coordination so you can focus on health.
- ✅ Monitoring & Control: We stay with you throughout the process, monitoring results and maintaining contact.
Want to check eligibility for a personalized vaccine?
We are here to provide clarity, explain the options, and accompany you to the leading companies worldwide.
Contact us for a consultation >>
