Friends, there are numbers that make you stop and take a deep breath before you see or read them.
Take a moment and think about metastatic pancreatic cancer – one of the most challenging diseases in oncology.
The current standard of care in the second- and third-line settings provides disease control in about 30% of cases.
Most patients do not respond to treatment.
Now pay attention to what was presented at ASCO 2026:
Two new drugs, Vopimetostat + Daraxonrasib, were given to patients with metastatic pancreatic cancer.
These were patients with a combination of two mutations called MTAP and a RAS mutation, in an ongoing Phase 1/2 study (not in Israel).
The following results were observed: it is important to note that this is an early study including 20 patients, 70% of whom had liver metastases.
The results:
• 92% – significant tumor shrinkage
• 100% – disease control
• 90% – progression-free at 6 months (this is not a typo) – 90%!
This number is a game changer.
It works because the combination targets two vulnerabilities at the same time: a PRMT5 inhibitor (vopimetostat) that affects MTAP-mutated cells, together with a RAS(ON) inhibitor (daraxonrasib) that blocks the growth pathway.
The synergy between them has already been demonstrated in preclinical data, and now it is proving itself in a study involving real patients.
What does this have to do with us?
At TRIAL•IN Pharma, this is exactly what we do. First, our oncologists identify treatments like these from around the world that may fit each patient according to their medical history and previous treatments. Then, like a guided missile, we launch the mission: connecting the most advanced treatment available worldwide with the patient – so that patients can live longer and with the best possible quality of life.
We cannot afford to sit quietly. Time is critical.
The earlier action is taken, the greater the chance of success.
Contact us:
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Yours sincerely,
Nir Erez
Trial-In Pharma
Source: Tango Therapeutics Corporate Presentation, June 2026.
Presented by Tango Therapeutics, Inc..
© 2026 Tango Therapeutics, Inc. All rights reserved. Used for educational and informational purposes only.
Presentation available at: Tango Therapeutics Corporate Presentation (June 2026).