However, toxicity is substantial, responses are rarely durable, and many locally advanced or metastatic patients are ineligible.
Padcev and Keytruda have each shown a survival benefit versus chemotherapy in Bladder Cancer, are not restricted by cisplatin eligibility, and warrant investigation as a first-line combination therapy in patients ineligible for cisplatin.
WHAT IS PADCEV?
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.
WHAT IS KEYTRUDA?
Keytruda, also called Pembrolizumab, is a humanized antibody used in cancer immunotherapy that treats melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, stomach cancer, cervical cancer, and certain types of breast cancer.
Common side effects include fatigue, musculoskeletal pain, decreased appetite, itchy skin (pruritus), diarrhea, nausea, rash, fever (pyrexia), cough, difficulty breathing (dyspnea), constipation, pain, and abdominal pain.
Keytruda was approved for medical use in the United States in 2014. In 2017, the US Food and Drug Administration (FDA) approved it for any unresectable or metastatic solid tumor with certain genetic anomalies.
It is on the World Health Organization’s List of Essential Medicines.
Twenty-nine patients had difficult side effects. The most common were increased lipase, maculopapular rash and fatigue.
One death was associated with the treatment.
73.3% of patient benefited from the treatment experiencing a decrease in lesions’ size. In these patients the median Survival was 25.6 months.
Padcev plus Keytruda showed a manageable safety profile.
Most patients experienced tumor shrinkage.
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