Doctors often struggle with treating advanced stages of breast cancer, especially Triple Negative Breast Cancer, TNBC. When the tumor is located in a confined area, it is relatively easier to treat with surgery and chemotherapy. However, when it spreads throughout the body, things get complicated.
Fortunately, ongoing research revealed a new drug that could potentially help thousands of patients with advanced stages of breast cancer.
What Is Triple-Negative Breast Cancer?
Triple-negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer, i.e. estrogen, progesterone and human epidermal growth factor (HER2). This makes it more aggressive and difficult to treat.
What is COSELA™ (Trilaciclib)?
Common side effects of taking this drug include:
- Hypocalcemia (i.e., low levels of calcium)
- Hypokalemia (i.e., low levels of potassium)
- Hypophosphatemia (i.e., low levels of phosphate)
How does Trilaciclib work?
Trilaciclib works by inhibiting molecules known as cyclin-dependent kinases 4 and 6 (CDK4/6). As a result of this action, the uncontrolled proliferation of cancer cells halts in an early phase of cell division.
Additionally, Trilaciclib induces programmed death (i.e., apoptosis) in cancerous cells, which is the core of every antitumor treatment.
In summary, this drug stops the growth of cancer cells through a complex cascade of biological reactions.
The results of clinical trials in Triple-Negative Breast Cancer
We should note that the Fast Track Designation indicates the great effectiveness of this medication and the need for innovative solutions to help TNBC patients.
The results that pushed the FDA to approve this drug were collected from a phase II trial that examined the effects of Trilaciclib on patients with metastatic TNBC before treatment with chemotherapy. The drug provided significant survival benefits, with a Progression-Free Survival (PFS) of 9 months. Patients who received chemotherapy alone had a PFS of 5.7 months. PFS is the time from the start of the treatment until the disease progresses, worsen.
As for the overall survival (OS), the results demonstrated:
- A median Survival of 19.8 in patients who received Trilaciclib with chemotherapy
- A median Survival of 12.6 in patients who received chemotherapy alone
Takeaway for Triple-Negative Breast Cancer patients
We hope that this article managed to highlight the potential benefits offered by Trilaciclib to cancer patients with TNBC in advanced stages.
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