Chemotherapy

What Is Chemotherapy?

Chemotherapy is a medications that damage the cells divide into the body.

Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body.

Chemotherapy’s impact has a range of side effects such as hair loss, loss of appetite, changes to bowel movements, fatigue, infection, hemorrhaging, incontinence, pain, and more.

Chemotherapy will be given with or without radiation

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Folfirinox is a combination of 4 anti cancer drugs:

Gemzar®, gemcitabine and one or two of this drugs:

Examples of standard chemotherapy protocols for treating breast cancer:

Texanes, e.g. Taxol, Taxotere, Docetaxel
Abraxane® (Paclitaxel)
Anthracyclines, e.g. Doxorubicin, Doxil, Epirubicin
Palatinum salts, e.g. Carboplatin and Cisplatin
Navelbine® (Vinorelbine)
Xeloda® (Capecitabine)
Gemzar® (Gemcitabine)

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation

Facts

The existing therapies used on stage 4 metastatic cancer are not curative, and this is a source to the need for innovative and effective treatment strategies in order to fight the disease.
The National Cancer Institute, NCI, highlights the fact that for a certain group of cancer patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success.
Currently, every patient will be offered the standard protocols described above. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute.

The opportunity

Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have already been recognized by the US Food & Drug Administration, the FDA, as “breakthrough drugs” and require further information to be approved.
An entire world of clinical trials, Compassionate drugs and advanced new cancer treatments are available worldwide.
It is important to know and have access to cutting edge cancer treatments that best match the unique medical condition of the patient and increase chances in winning the fight against compared to the standard care offered.

Read our publications on innovative treatments and chemotherapies:

Lung Cancer Treated with Electric Fields – Strongly Positive Results

Background Interim analysis of the phase 3 LUNAR trial led to a recommendation to reduce the number of lung cancer patients required. This recommendation is

Small Cell Lung Cancer – Fast Track Designation to Onivyde

Background The FDA granted fast track designation to Onivyde injection for the treatment of patients with Small Cell Lung Cancer, SCLC, who progressed following a

Ovarian Cancer – Fast Track Designation to GEN-1 Immunotherapy

Background Women with advanced ovarian cancer have limited treatment options in the standard of care and therefore they have much better chances and hope in

Gastric cancer - Adding Bemarituzumab to chemo improves the results

Gastric Cancer – Bemarituzumab Plus Chemo Improves Outcomes

Background Gastric cancer has a new target to attack: FGFR2b. Anew drug, “Bemarituzumab”, targets FGFR2b. When Bemarituzumab was given with chemotherapy, the combination postponed the

Colorectal cancer – Onvansertib, a Novel Oral PLK1 Inhibitor

Background On average, KRAS is mutated in approximately 50% of patients with colorectal cancer. Chemotherapy in combination with targeted drugs is standard of care option

Ovarian, fallopian tube or primary peritoneal cancers - Keytruda, Avastin and Cyclophosphamide

Ovarian Cancer – 95% benefit with Keytruda, Avastin and Cyclophosphamide

Background Treatment options for recurrent ovarian cancer are of limited clinical benefit and adversely affect patient quality of life, representing an unmet need for tolerable

Metastatic breast cancer - Xeloda plus Utidelone extends life

Metastatic Breast Cancer – Utidelone plus Xeloda prolong life

Background Patients with advanced or metastatic breast cancer have very few effective treatment options. The lack of successful therapeutic strategies is reflected by a low

Esophageal cancer at 70 plus? Icotinib plus radiation

Background Concurrent chemoradiation therapy remains the standard therapy for unresectable Esophageal Squamous Cell Carcinoma patients. However, its feasibility and efficiency for older patients are being

Head and Neck Cancer – Debio1143 prolonged patient lives

Background 3-year follow-up results from the randomized phase II study assessing the efficacy and safety of Debio 1143 in combination with chemo-radiation therapy vs. chemo-radiation

Trial – Berzosertib can neutralize the cancer’s ability to repair itself

Berzosertib – Trial Rational Berzosertib is the first to be studied of a new family of treatments. These drugs block a protein involved in DNA

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Improve therapeutic outcomes, prolong life and quality of life, is our main business.
We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

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Home » Chemotherapy » Page 5

Lung Cancer Treated with Electric Fields – Strongly Positive Results

Background

Interim analysis of the phase 3 LUNAR trial led to a recommendation to reduce the number of lung cancer patients required.

This recommendation is based on the strongly positive data gathered so far from the current patient population treated with tumor-treating fields.

About Tumor Treating Fields

Tumor Treating Fields, or TTFields, are electric fields that disrupt cancer cell division.

When cancer develops, rapid and uncontrolled division of unhealthy cells occurs. Electrically charged proteins within the cell are critical for cell division, making the rapidly dividing cancer cells vulnerable to electrical interference.

As healthy cells differ from cancer cells in their division rate, geometry and electric properties, the frequency of TTFields can be tuned to specifically affect the cancer cells while leaving healthy cells mostly unaffected.

Use of Tumor Treating Fields for the treatment of NSCLC is investigational only.

About the Study in Lung Cancer

This is a phase 3 LUNAR trial (NCT02973789) in patients with stage IV Non–Small Cell Lung Cancer, NSCLC, after progression on or after platinum-base chemotherapy.

The interim analysis included data taken from 210 patients with a data monitoring committee recommendation to reduce the sample size from 534 patients to approximately 276 patients.

It is possibly unethical given the available data.

The TTFields were given concurrent with Immunotherapies, such as Keytruda, Opdivo and others or the chemotherapy Taxotere.

Treatment in the TTFields arm of the current trial requires that patients wear 4 electrically insulated electrode arrays on the chest and that they maintain regular daily routine with the therapy.

Side Effects

There was no evidence of increased systemic toxicity when patients were treated with TTFields.

Conclusion

When a treatment works, the path for approval gets shortened. These are groundbreaking news to stage 4, metastatic, Non-Small Cell Lung Cancer patients.

Contact us to find out what is the best treatment for YOU

TRIAL•IN Pharma

Because we, do not give up on life!

Call center +44.2082.426.039

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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

Article categories

Chemotherapy

What Is Chemotherapy?

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Examples of standard chemotherapy protocols for treating breast cancer:

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation

Read our publications on innovative treatments and chemotherapies:

קטגוריות המאמרים

Tags

Lung Cancer Treated with Electric Fields – Strongly Positive Results

Background

About Tumor Treating Fields

About the Study in Lung Cancer

Side Effects

Conclusion

קטגוריות המאמרים

Tags