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Chemotherapy

What Is Chemotherapy?

Chemotherapy is a medications that damage the cells divide into the body.

Unlike surgery or radiation, chemotherapy works all over the body and is not focused. This means that it can eliminate cancerous lesions, such as metastasis, that have developed in various organs of the body.

Chemotherapy’s impact has a range of side effects such as hair loss, loss of appetite, changes to bowel movements, fatigue, infection, hemorrhaging, incontinence, pain, and more.

Chemotherapy will be given with or without radiation

Examples of standard chemotherapy protocols for treating pancreatic cancer:

Folfirinox is a combination of 4 anti cancer drugs:

  1. Leucovorin
  2. Adrucil®, (Fluorouracil, 5-FU)
  3. Camptosar®, Campto®, (Irinotecan)
  4. Eloxatin®, (Oxaliplatin)

Gemzar®, gemcitabine and one or two of this drugs:

Examples of standard chemotherapy protocols for treating breast cancer:

Examples of standard chemotherapy protocols for treating skin cancer or Melanoma:

Chemotherapy innovation

Facts

  1. The existing therapies used on stage 4 metastatic cancer are not curative, and this is a source to the need for innovative and effective treatment strategies in order to fight the disease.
  2. The National Cancer Institute, NCI, highlights the fact that for a certain group of cancer patients, the best treatment option is to join one of the many clinical trials existing worldwide aiming to increase their chances of therapeutic success.
  3. Currently, every patient will be offered the standard protocols described above. Sometimes the oncologist may suggest integrating these therapies with trials carried out in the institute.

The opportunity

  1. Advances in cancer therapies may be found in clinical trials prescribing cutting edge, innovative drugs, some of which have already been recognized by the US Food & Drug Administration, the FDA, as “breakthrough drugs” and require further information to be approved.
  2. An entire world of clinical trials, Compassionate drugs and advanced new cancer treatments are available worldwide.
  3. It is important to know and have access to cutting edge cancer treatments that best match the unique medical condition of the patient and increase chances in winning the fight against compared to the standard care offered.

Read our publications on innovative treatments and chemotherapies:

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Improve therapeutic outcomes, prolong life and quality of life, is our main business.
We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

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Meet Zongertinib (Hernexeos) – a breakthrough drug for patients with HER2‑mutant lung cancer

Meet Zongertinib (Hernexeos) – a breakthrough drug for patients with HER2‑mutant lung cancer

Zongertinib (brand name: Hernexeos) is an innovative oral medication that acts as a selective HER2 receptor inhibitor and is intended for patients with non‑squamous NSCLC lung cancer who carry a HER2 mutation in the TKD domain.

The drug was approved by the FDA in August 2025 via an accelerated process, for patients who have already undergone at least one systemic treatment for their disease.

🔬 What did the studies show?
In the BEAMION LUNG‑1 phase 1a/1b study – an overall response rate (ORR) of approximately 71%–75%.
Durable response (DOR) was seen among patients who had not received prior ADC treatment.
Even among patients previously treated with HER2‑targeted ADC drugs – a response was observed (ORR of approx. 44%).

💊 Safety profile
Most side effects were mild (grade 1–2).
Most common: diarrhea (51%), rash (27%).
No cases of interstitial lung disease (ILD) were reported – a known issue with ADC‑type therapies.

Why is it important?

This is an effective, convenient, and safe treatment that offers new hope to patients with HER2‑mutant lung cancer. The drug is taken orally – unlike intravenous therapies – and provides a significant response with a chance to improve both life expectancy and quality of life.

Talk to us so we can help you find and access the most advanced and researched drugs and treatments in the world – for you.

Trial‑In Pharma
Because we don’t give up on life!

📞 24/7 Call Center: 072‑3902977


Read more (FDA & BI official sources):
FDA grants accelerated approval to zongertinib for non‑squamous NSCLC with HER2 TKD activating mutations – official FDA announcement from August 2025 on the accelerated approval of Zongertinib (Hernexeos) for HER2‑mutant NSCLC lung cancer.
U.S. Food and Drug Administration
https://www.boehringer-ingelheim.com/us/media/press-releases/hernexeos-zongertinib-tablets-gains-accelerated-approval

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Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

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