Background Lurbinectedin, a selective inhibitor of oncogenic transcription, has shown preclinical antitumor activity against homologous recombination repair-deficient (HRD) models and preliminary clinical activity in BRCA1/2 breast cancer. Introduction Breast cancer…
Background - Glioblastoma and CV-01 Glioblastoma is a diffuse, infiltrative disease with tumor cells invading far beyond the borders of the visible tumor. The diffuse nature of Glioblastomas, often across…
Background Among women, ovarian cancer is the 5th most common type of cancer. The risk of getting this cancer in one lifetime is 1 in 78. Treatment with Apatinib plus…
Background The antibody-drug conjugate Trodelvy offers statistically and clinically significant benefits for patients with heavily pretreated HR+/HER2- breast cancer, according to results of the TROPiCS-02 study, recently presented. HR+/HER2- is…
Overview Colorectal cancer is one of the most common types of malignant tumors in humans. According to statistics, the risk of developing this tumor in a lifetime is: Around 1…
Background Biliary tract cancer is a group of malignancies that includes intrahepatic and extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer. It is typically diagnosed at advanced stages for…
Importance Endometrial cancer is often hormone-dependent and treated with aromatase inhibitors, (AIs). The uncontrolled PI3K-AKT-mTOR pathway observed in this type of cancer drives hormonal resistance. Therefore, there is rationale of…
Background Epidermal Growth Factor Receptor, EGFR, mutations are one of the most common driver mutations in Non–Small-Cell Lung Cancer, NSCLC. Tagrisso, a third-generation EGFR tyrosine kinase inhibitor, TKI, is approved…
Purpose This Phase 1/2 study evaluated safety and efficacy of a topical anhydrous ointment, SOR007, which contains submicron particles of the chemotherapy Taxol primarily in breast cancer patients with cutaneous…
Overview Cervical cancer is a malignant tumor that grows in different parts of the cervix. The vast majority of cervical cancers are linked to an infection by the human papillomavirus…