Background Adagrasib, also called “Krazati”, is a tablet taken by mouth which inhibits KRAS G12C mutation. It has shown clinical activity in pretreated patients with several tumor types, including colorectal…
Background The use of cannabis for therapeutic benefit has risen exponentially over the past few years with strong public belief in its benefit. This is despite very limited evidence of…
About Locally Advanced Unresectable Metastatic Gastric Cancer and Gastroesophageal Junction Cancer (GEJ) Gastric cancer is the fifth most diagnosed cancer worldwide. Signs and symptoms can include indigestion or heartburn; pain…
In Short This phase Ib/II study evaluated the efficacy and safety of Lenvima combined with Halaven in the treatment of patients with advanced leiomyosarcoma and liposarcoma. The results showed that…
Background about Glioblastoma and the new drug Glioblastoma (GBM) has a poor prognosis, and patients with Epidermal Growth Factor Receptor (EGFR) amplification have an even worse prognosis. Nimotuzumab is an…
The Rational for Vitamin C in Colorectal Cancer The use of vitamin C in cancer treatment can be traced to more than 40 years ago. Back then two retrospective studies…
Background In this randomized clinical trial that included 585 patients with extensive-stage Small Cell Lung Cancer, SCLC, who had not previously received systemic therapy, Seplulimab plus chemotherapy, compared with Placebo…
Background A significant period until disease progression was seen in patients with metastatic renal cell cancer (RCC) receiving the triplet combination of Cometriq plus Yervoy and Opdivo, according to a…
BACKGROUND Cisplatin-based combination chemotherapy remains the standard of care for locally advanced or metastatic bladder cancer. However, toxicity is substantial, responses are rarely durable, and many locally advanced or metastatic…
Background Lurbinectedin, a selective inhibitor of oncogenic transcription, has shown preclinical antitumor activity against homologous recombination repair-deficient (HRD) models and preliminary clinical activity in BRCA1/2 breast cancer. Introduction Breast cancer…