Fortunately, a new body of research suggests that a combination treatment for GBM can improve the outcome of these patients.
What is the new combination treatment for Glioblastoma?
The investigated combination treatment consists of three modalities, each in itself, is approved for Glioblastoma:
The first treatment uses electric fields of intermediate frequency and low intensity to interfere with cell division. It is formally known as an alternating electric field therapy.
What do the results tell us?
Investigators enrolled 25 patients who had a median age of 61 years. To be part of the study, there were some inclusion criteria, which included:
- Histological confirmation of grade IV Glioblastoma, GBM
- Previous maximal safe resection procedure
- A history of receiving radiotherapy with Temodar
- Known MGMT methylation status (i.e., a specific tumor marker)
After following up with the patients 9 months later, the median Progression-Free Survival (PFS, i.e.,the time until the disease progressed and the treatment stopped working) was 11.2 months. Interestingly, 24% of patients had a Complete Remission or Partial Response which is a reduction in the size of the tumor.
As for the side effects, 4 patients developed thrombosis, 3 had a seizure episode, and 2 patients developed metabolic disturbances.
William Doyle, Novocure’s Executive Chairman, stated that “We are very encouraged by the results of the 2-THE-TOP study, especially in light of the poor prognostic factors of the patient population.”
He also added that “Dr. Tran’s research is an important continuation of our exploration of synergies between TTFields and immunotherapy agents. We would like to thank Dr. Tran and the patients enrolled in the 2-THE-TOP trial for their ingenuity and courage.”
These results give us hope about the treatment of newly diagnosed GBM.
Takeaway message for Glioblastoma
The new combination treatment seems to give promising results for patients with Glioblastoma. Continuous research in this field will hopefully yield more concrete results.
We hope that this article managed to highlight the important points of the new research regarding Glioblastoma.
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