Triple Negative Breast Cancer patients – Capivasertib helps you survive


The trial was designed to evaluate the safety and efficacy of adding Capivasertib to Taxol as first-line therapy for metastatic TNBC patients.


A total of 140 patients were enrolled and randomized to two groups to received Taxol with either Capivasertib or Placebo. The primary goal of the study was the median time the disease has worsened. Secondary goals included survival and median time the disease has worsened and survival in the subgroup with PIK3CA/AKT1/PTEN alterations tumor and safety.


  • In this randomized phase II trial, 140 women with metastatic triple-negative breast cancer, TNBC, received Taxol with either Capivasertib or Placebo as the first treatment.
  • The median time the disease has worsened was 5.9 with Capivasertib-Taxol vs 4.2 months with Placebo-Taxol and median survival was 19.1 with Capivasertib-Taxol  vs 12.6 months with Placebo-Taxol
  • The median time the disease has worsened was more pronounced in patients with PIK3CA/AKT1/PTEN–altered tumors 9.3 months vs 3.7 months.


The most common adverse events in those treated with Capivasertib plus Taxol versus Placebo plus Taxol, respectively, were diarrhea, infection , neutropenia , rash and fatigue.


Addition of Capivasertib to first-line Taxol therapy for metastatic TNBC patients resulted in significantly longer time until disease worsening and longer survival. Benefits were more pronounced in patients with PIK3CA/AKT1/PTEN-altered tumors.

The best treatment for a cancer patient is to get the most advanced cancer drugs in advanced stages of development. There, the hope and the chance to extend life go far beyond the standard protocols.

Contact us to find out what is the best treatment for YOU


Do not give up on life!

Contact us 24/7 for free service matching:

Call center +44.2082.426.039


For further reading

To check if our service suits your case
We need to talk

Improve therapeutic outcomes, prolong life and quality of life, is our main business.
We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

Article categories

קטגוריות המאמרים

Popular topics