Facebook
Twitter
LinkedIn
WhatsApp

Genomic Testing

What is Genetic testing?

Genetic testing, Genomic Testing, is a test to examine a person’s risk of developing hereditary disease or to tailor personalized medication.

The process of analyzing the DNA of cells or tissues to look for genetic changes that may be a sign of a disease such as cancer.

For example, testing mutations in the BRCA gene for early detection or preventing the development of breast cancer.

What is Gene? What is Genome?

Gene is a fragment in the DNA strand that encodes physiological features, for example, eye color.

The genes genes are inherited upon cell division when the DNA molecule replicates, and each new cell receives a copy of the replicated DNA.

Genome is the full system of all the genes in an organism.

In humans, all genes are located on structures called chromosomes. Chromosomes are complexes of DNA and proteins bind to each other.

Almost every cell in the body contains a complete copy of the genome. The genome contains all the information a person needs for development and growth.

The Genome study provides an understanding of how cancer cells are formed and respond to therapy.

People with different genetic will respond differently to a particular drug.

For example, So certain drugs that are not given to people with certain DNA mutations.

What is a Mutation?

Mutation is a change of the DNA sequence in the cell.

Mutations can be caused by errors during cell division, or they can be caused by exposure to substances harmful to DNA (free radicals, asbestos, etc.).

Mutations can be harmful, beneficial, or have no effect.

When they appear in egg or sperm cells, they can be inherited.

Sometimes cancer is seen in families more often than was randomly expected (coincidence). This cancer often occurs at a young age, and may indicate the presence of a genetic mutation that increases the risk of cancer. It also constitutes a sign of environmental factors affecting life in a common environment.

If mutations occur in other types of cells, they are not inherited and are called somatic mutations.

Mutations can lead to cancer or other diseases

When is it important to perform genetic testing?

Why it is important to do genetic testing?

In cancer, personalized medicine uses the patient’s specific disease characteristics and medical background to form a personalized therapy program.

Read our publications on genetic and genomic testing and other innovative treatments for  cancer:

To check if our service suits your case
We need to talk

Improve therapeutic outcomes, prolong life and quality of life, is our main business.
We support access to and expand cancer treatments beyond the standard of care, with the most advanced and innovative treatment options in the world, personally matching the individual cancer patient’s medical condition and with the support of top tier oncologists.

Article categories

קטגוריות המאמרים

Popular topics

Facebook
Twitter
LinkedIn
WhatsApp

Top developments in 2018 in treating breast cancer

The FDA has approved the drug Olaparib (Lynparza®)

For the treatment of stage 4 metastatic breast cancer patients, whose growth expresses mutations in the BRCA gene. The approval was given following the results of a study called OLYMPIAD, which showed a significant advantage over the standard treatment. There is no doubt that those patients who received the Olaparib during the study gained life, years before it was approved.

or further reading:
https://www.nejm.org/doi/full/10.1056/NEJMoa1706450

Results of the TAILORx study

This is the study that changed the face of women with breast cancer (!!!) at an early stage and received midpoint score on Oncotype DX: they do not need postoperative chemotherapy. The findings save thousands of women from the harmful effects of chemotherapy, and patients who participated in the study, received quality of life before the results were published.

For further reading:

https://www.asco.org/…/most-women-early-stage-breast-cancer…

A case study of metastatic breast cancer patient who developed resistance to any standard treatment, chemotherapy and hormonal treatment.

The 49-year-old patient is ER positive and HER2 negative. She joined the Phase II study in metastatic breast cancer patients. In the study, the researchers found 62 mutations in their cancer cells in the first stage and in the second stage, they detected cells from their immune system that detect and attack at least one mutant from the 62. The same cells that were isolated from the rest in laboratory conditions outside the woman’s body, multiplied and returned back to the patient, in billions.

She reached full remission and remained in remission at 22-month follow-up after treatment started!

Until this investigational treatment will be approved and available to the general population, it can take another 10 years and the same patient who joined the study today – has earned her life long before everyone else.

For further reading:

 

Personalized immunotherapy has resulted in complete remission of metastatic breast cancer, stage 4

https://www.nature.com/articles/s41591-018-0040-8

 

Remember that you can do otherwise! It is possible to join trials and win life and quality of life far more than to accept the standard

No Cost service compatibility check
Please fill in the details and we will back to you as soon as possible

Improving therapeutic success, extending life and quality of life are our main business. We extend to metastatic cancer patients and patients with brain tumors, the most advanced treatment options in the world and the best experts in Israel and abroad.

Article categories

קטגוריות המאמרים

Popular topics